Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 853068..853482 Replicon chromosome
Accession NZ_CP031131
Organism Staphylococcus aureus strain E16SA093

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DU470_RS04365 Protein ID WP_025174939.1
Coordinates 853068..853319 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DU470_RS14465 Protein ID WP_000028424.1
Coordinates 853309..853482 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU470_RS04315 848416..849090 + 675 WP_063456299.1 hypothetical protein -
DU470_RS04320 849200..849859 - 660 WP_016028252.1 hypothetical protein -
DU470_RS04325 849905..850675 + 771 WP_114561606.1 conserved phage C-terminal domain-containing protein -
DU470_RS04330 850685..851458 + 774 WP_000803028.1 ATP-binding protein -
DU470_RS04335 851452..851610 + 159 WP_114561607.1 hypothetical protein -
DU470_RS04340 851624..851845 + 222 WP_001123681.1 DUF3269 family protein -
DU470_RS04345 851856..852260 + 405 WP_000049798.1 DUF1064 domain-containing protein -
DU470_RS04350 852265..852450 + 186 WP_016028253.1 DUF3113 family protein -
DU470_RS04355 852451..852807 + 357 WP_001557189.1 phage protein -
DU470_RS04360 852811..853053 + 243 WP_000131381.1 phi PVL orf 51-like protein -
DU470_RS04365 853068..853319 + 252 WP_025174939.1 DUF1024 family protein Toxin
DU470_RS14465 853309..853482 + 174 WP_000028424.1 hypothetical protein Antitoxin
DU470_RS04370 853483..853764 + 282 WP_000454994.1 hypothetical protein -
DU470_RS14470 853765..853926 + 162 WP_000889683.1 hypothetical protein -
DU470_RS04375 853941..854474 + 534 WP_016028255.1 dUTP diphosphatase -
DU470_RS04380 854511..854717 + 207 WP_000195826.1 DUF1381 domain-containing protein -
DU470_RS04385 854714..854905 + 192 Protein_807 hypothetical protein -
DU470_RS04390 854906..855109 + 204 WP_001072793.1 hypothetical protein -
DU470_RS04395 855102..855251 + 150 WP_114561608.1 transcriptional regulator -
DU470_RS04400 855252..855614 + 363 WP_000383791.1 hypothetical protein -
DU470_RS04405 855615..855761 + 147 WP_000989961.1 hypothetical protein -
DU470_RS04410 855776..856195 + 420 WP_000058634.1 transcriptional regulator -
DU470_RS04415 856382..856822 + 441 WP_009560332.1 terminase small subunit -
DU470_RS04420 856809..858086 + 1278 WP_009560330.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 839443..885787 46344


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9361.22 Da        Isoelectric Point: 3.8464

>T108520 WP_025174939.1 NZ_CP031131:853068-853319 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T108520 NZ_CP031131:853068-853319 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT108520 WP_000028424.1 NZ_CP031131:853309-853482 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT108520 NZ_CP031131:853309-853482 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References