Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2429448..2429965 Replicon chromosome
Accession NZ_CP031130
Organism Staphylococcus aureus strain F17SA003

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DU471_RS12680 Protein ID WP_000113262.1
Coordinates 2429448..2429714 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DU471_RS12685 Protein ID WP_000584499.1
Coordinates 2429714..2429965 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU471_RS12655 2424871..2425407 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
DU471_RS12660 2425641..2426465 - 825 WP_000572040.1 formate/nitrite transporter family protein -
DU471_RS12665 2426682..2426864 - 183 WP_000079142.1 hypothetical protein -
DU471_RS12670 2426951..2427418 - 468 WP_000153344.1 SRPBCC domain-containing protein -
DU471_RS12675 2427604..2429154 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DU471_RS12680 2429448..2429714 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DU471_RS12685 2429714..2429965 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DU471_RS12690 2430130..2430231 - 102 Protein_2344 hypothetical protein -
DU471_RS12695 2430238..2430837 - 600 WP_000162803.1 DsbA family protein -
DU471_RS12700 2430856..2431218 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DU471_RS12705 2431473..2432723 + 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
DU471_RS12710 2432820..2433551 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
DU471_RS12715 2433548..2434267 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T108515 WP_000113262.1 NZ_CP031130:c2429714-2429448 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T108515 NZ_CP031130:c2429714-2429448 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT108515 WP_000584499.1 NZ_CP031130:c2429965-2429714 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT108515 NZ_CP031130:c2429965-2429714 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References