Detailed information of TA system TA108509

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF4/-
• Location: 2000413..2000712
• Replicon: chromosome
• Accession: NZ_CP031130
• Organism: Staphylococcus aureus strain F17SA003

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DU471_RS10310
• Protein ID: WP_011447039.1
• Coordinates: 2000536..2000712 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2000413..2000468 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DU471_RS10265	1995755..1996015	+	261	WP_001791826.1	hypothetical protein	-
DU471_RS10270	1996068..1996408	-	341	Protein_1893	complement inhibitor SCIN-A	-
DU471_RS10275	1997092..1997541	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DU471_RS10280	1997636..1997971	-	336	Protein_1895	SH3 domain-containing protein	-
DU471_RS10290	1998621..1999112	-	492	WP_000919350.1	staphylokinase	-
DU471_RS10295	1999303..2000058	-	756	WP_000861038.1	CHAP domain-containing protein	-
DU471_RS10300	2000070..2000324	-	255	WP_000611512.1	phage holin	-
DU471_RS10305	2000376..2000483	+	108	WP_001791821.1	hypothetical protein	-
-	2000405..2000544	+	140	NuclAT_0	-	-
-	2000405..2000544	+	140	NuclAT_0	-	-
-	2000405..2000544	+	140	NuclAT_0	-	-
-	2000405..2000544	+	140	NuclAT_0	-	-
-	2000413..2000468	+	56	-	-	Antitoxin
DU471_RS10310	2000536..2000712	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DU471_RS10315	2000862..2001158	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DU471_RS10320	2001216..2001503	-	288	WP_001040261.1	hypothetical protein	-
DU471_RS10325	2001550..2001702	-	153	WP_001153681.1	hypothetical protein	-
DU471_RS10330	2001692..2005477	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / scn / chp / sak / hlb / groEL	1996068..2048277	52209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T108509 WP_011447039.1 NZ_CP031130:c2000712-2000536 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T108509 NZ_CP031130:c2000712-2000536 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT108509 NZ_CP031130:2000413-2000468 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin