Detailed information of TA system TA108504

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 826892..827306
• Replicon: chromosome
• Accession: NZ_CP031130
• Organism: Staphylococcus aureus strain F17SA003

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DU471_RS04240
• Protein ID: WP_114604573.1
• Coordinates: 826892..827143 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DU471_RS14420
• Protein ID: WP_000028424.1
• Coordinates: 827133..827306 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DU471_RS04190	822231..822902	+	672	WP_016028251.1	hypothetical protein	-
DU471_RS04195	823012..823671	-	660	WP_016028252.1	hypothetical protein	-
DU471_RS04200	823717..824487	+	771	WP_000190226.1	conserved phage C-terminal domain-containing protein	-
DU471_RS04205	824497..825270	+	774	WP_000803028.1	ATP-binding protein	-
DU471_RS04210	825264..825422	+	159	WP_000256589.1	hypothetical protein	-
DU471_RS04215	825436..825657	+	222	WP_001123681.1	DUF3269 family protein	-
DU471_RS04220	825668..826072	+	405	WP_000049798.1	DUF1064 domain-containing protein	-
DU471_RS04225	826077..826262	+	186	WP_016028253.1	DUF3113 family protein	-
DU471_RS04230	826263..826631	+	369	WP_016028254.1	hypothetical protein	-
DU471_RS04235	826635..826877	+	243	WP_000131389.1	hypothetical protein	-
DU471_RS04240	826892..827143	+	252	WP_114604573.1	DUF1024 family protein	Toxin
DU471_RS14420	827133..827306	+	174	WP_000028424.1	hypothetical protein	Antitoxin
DU471_RS04245	827307..827588	+	282	WP_000454994.1	hypothetical protein	-
DU471_RS14425	827589..827750	+	162	WP_000889683.1	hypothetical protein	-
DU471_RS04250	827765..828298	+	534	WP_016028255.1	dUTP diphosphatase	-
DU471_RS04255	828335..828541	+	207	WP_016028256.1	DUF1381 domain-containing protein	-
DU471_RS04260	828538..828711	+	174	WP_000595257.1	transcriptional activator RinB	-
DU471_RS04265	828712..829074	+	363	WP_000383791.1	hypothetical protein	-
DU471_RS04270	829075..829221	+	147	WP_000989961.1	hypothetical protein	-
DU471_RS04275	829236..829655	+	420	WP_000058634.1	transcriptional regulator	-
DU471_RS04280	829842..830282	+	441	WP_009560332.1	terminase small subunit	-
DU471_RS04285	830269..831546	+	1278	WP_009560330.1	PBSX family phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	813310..856955	43645

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9447.32 Da
• Isoelectric Point: 3.8464

>T108504 WP_114604573.1 NZ_CP031130:826892-827143 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVREGIELDEAIGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T108504 NZ_CP031130:826892-827143 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAATAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT108504 WP_000028424.1 NZ_CP031130:827133-827306 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT108504 NZ_CP031130:827133-827306 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA