Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1733982..1734463 Replicon chromosome
Accession NZ_CP031114
Organism Bordetella pertussis strain UK76

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DVA65_RS08410 Protein ID WP_225975616.1
Coordinates 1734284..1734463 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DVA65_RS08405 Protein ID WP_019247905.1
Coordinates 1733982..1734281 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA65_RS08395 (DVA65_08425) 1730090..1730764 - 675 WP_010930489.1 response regulator transcription factor -
DVA65_RS08400 (DVA65_08430) 1730894..1733968 + 3075 WP_023995112.1 autotransporter SphB2 -
DVA65_RS08405 (DVA65_08435) 1733982..1734281 - 300 WP_019247905.1 NadS family protein Antitoxin
DVA65_RS08410 (DVA65_08440) 1734284..1734463 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DVA65_RS08415 (DVA65_08445) 1734596..1735219 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
DVA65_RS08420 (DVA65_08450) 1735463..1736332 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
DVA65_RS08425 (DVA65_08455) 1736310..1737254 - 945 WP_010930494.1 LysR family transcriptional regulator -
DVA65_RS08430 (DVA65_08460) 1737340..1738362 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
DVA65_RS08435 (DVA65_08465) 1738379..1739152 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T108488 WP_225975616.1 NZ_CP031114:c1734463-1734284 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T108488 NZ_CP031114:c1734463-1734284 [Bordetella pertussis]
ATACGAAAGATGCATTACGGCCGGCAAGGCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGA
TTGTCAGATCTACATGCTTGCGGCTTATGCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCG
AACTGGTCAAGGAGCTGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT108488 WP_019247905.1 NZ_CP031114:c1734281-1733982 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT108488 NZ_CP031114:c1734281-1733982 [Bordetella pertussis]
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAGGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACAGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGCACGCTGCAGAACTGGGAGCAAGGGCACCGCAATCCGACGGGCCCTGCCATGGCG
CTTCTGAAAATAGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References