Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2320829..2321310 Replicon chromosome
Accession NZ_CP031113
Organism Bordetella pertussis strain UK39

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DVA63_RS11095 Protein ID WP_225975616.1
Coordinates 2320829..2321008 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DVA63_RS11100 Protein ID WP_019247905.1
Coordinates 2321011..2321310 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA63_RS11070 (DVA63_11160) 2316140..2316913 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
DVA63_RS11075 (DVA63_11165) 2316930..2317952 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
DVA63_RS11080 (DVA63_11170) 2318038..2318982 + 945 WP_010930494.1 LysR family transcriptional regulator -
DVA63_RS11085 (DVA63_11175) 2318960..2319829 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
DVA63_RS11090 (DVA63_11180) 2320073..2320696 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
DVA63_RS11095 (DVA63_11185) 2320829..2321008 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DVA63_RS11100 (DVA63_11190) 2321011..2321310 + 300 WP_019247905.1 NadS family protein Antitoxin
DVA63_RS11105 (DVA63_11195) 2321324..2324398 - 3075 WP_023995112.1 autotransporter SphB2 -
DVA63_RS11110 (DVA63_11200) 2324528..2325202 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2288327..2450970 162643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T108485 WP_225975616.1 NZ_CP031113:2320829-2321008 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T108485 NZ_CP031113:2320829-2321008 [Bordetella pertussis]
ATACGAAAGATGCATTACGGCCGGCAAGGCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGA
TTGTCAGATCTACATGCTTGCGGCTTATGCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCG
AACTGGTCAAGGAGCTGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT108485 WP_019247905.1 NZ_CP031113:2321011-2321310 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT108485 NZ_CP031113:2321011-2321310 [Bordetella pertussis]
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAGGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACAGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGCACGCTGCAGAACTGGGAGCAAGGGCACCGCAATCCGACGGGCCCTGCCATGGCG
CTTCTGAAAATAGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References