Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2320851..2321332 Replicon chromosome
Accession NZ_CP031112
Organism Bordetella pertussis strain UK38

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DVA62_RS11100 Protein ID WP_225975616.1
Coordinates 2320851..2321030 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DVA62_RS11105 Protein ID WP_019247905.1
Coordinates 2321033..2321332 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA62_RS11075 (DVA62_11195) 2316162..2316935 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
DVA62_RS11080 (DVA62_11200) 2316952..2317974 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
DVA62_RS11085 (DVA62_11205) 2318060..2319004 + 945 WP_010930494.1 LysR family transcriptional regulator -
DVA62_RS11090 (DVA62_11210) 2318982..2319851 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
DVA62_RS11095 (DVA62_11215) 2320095..2320718 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
DVA62_RS11100 (DVA62_11220) 2320851..2321030 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DVA62_RS11105 (DVA62_11225) 2321033..2321332 + 300 WP_019247905.1 NadS family protein Antitoxin
DVA62_RS11110 (DVA62_11230) 2321346..2324420 - 3075 WP_023995112.1 autotransporter SphB2 -
DVA62_RS11115 (DVA62_11235) 2324550..2325224 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T108482 WP_225975616.1 NZ_CP031112:2320851-2321030 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T108482 NZ_CP031112:2320851-2321030 [Bordetella pertussis]
ATACGAAAGATGCATTACGGCCGGCAAGGCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGA
TTGTCAGATCTACATGCTTGCGGCTTATGCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCG
AACTGGTCAAGGAGCTGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT108482 WP_019247905.1 NZ_CP031112:2321033-2321332 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT108482 NZ_CP031112:2321033-2321332 [Bordetella pertussis]
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAGGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACAGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGCACGCTGCAGAACTGGGAGCAAGGGCACCGCAATCCGACGGGCCCTGCCATGGCG
CTTCTGAAAATAGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References