Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3422066..3422637 Replicon chromosome
Accession NZ_CP031093
Organism Hydrocarboniclastica marina strain soil36-7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag soil367_RS15075 Protein ID WP_136549874.1
Coordinates 3422066..3422344 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag soil367_RS15080 Protein ID WP_136549875.1
Coordinates 3422344..3422637 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
soil367_RS15055 3417454..3418422 + 969 WP_136549870.1 ATP-binding protein -
soil367_RS15060 3418458..3420941 + 2484 WP_136549871.1 S8 family peptidase -
soil367_RS15065 3421212..3421700 + 489 WP_136549872.1 hypothetical protein -
soil367_RS15070 3421714..3422004 + 291 WP_136549873.1 hypothetical protein -
soil367_RS15075 3422066..3422344 + 279 WP_136549874.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
soil367_RS15080 3422344..3422637 + 294 WP_136549875.1 HigA family addiction module antidote protein Antitoxin
soil367_RS15085 3422951..3423187 + 237 WP_136549876.1 hypothetical protein -
soil367_RS15090 3423536..3423814 + 279 WP_136549877.1 type II toxin-antitoxin system RelE/ParE family toxin -
soil367_RS15095 3423827..3424126 + 300 WP_172962364.1 HigA family addiction module antidote protein -
soil367_RS15100 3424256..3424414 - 159 Protein_2967 type II toxin-antitoxin system YoeB family toxin -
soil367_RS15105 3424413..3424649 - 237 WP_136549878.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
soil367_RS15110 3424889..3427018 + 2130 WP_136549879.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3401192..3671756 270564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10596.00 Da        Isoelectric Point: 9.4399

>T108397 WP_136549874.1 NZ_CP031093:3422066-3422344 [Hydrocarboniclastica marina]
MIKSFRHKGLKRFYATGNTAGIQSDHAKKLRLQLAALDTAASVTDMDIPGFRLHPMKGSDKGRWSIWVNGNWRMTFEFED
GNAYVLDYEDYH

Download         Length: 279 bp

>T108397 NZ_CP031093:3422066-3422344 [Hydrocarboniclastica marina]
ATGATTAAATCATTCCGTCATAAAGGGCTAAAGCGCTTTTACGCGACTGGCAATACCGCTGGCATACAATCAGATCACGC
CAAGAAACTGCGCTTGCAGCTTGCGGCCCTCGATACAGCCGCTTCAGTGACGGATATGGACATCCCCGGTTTCCGGCTTC
ATCCGATGAAGGGGAGCGACAAAGGACGATGGTCAATCTGGGTTAACGGAAACTGGCGCATGACGTTCGAGTTTGAGGAC
GGCAACGCTTACGTTCTTGATTATGAGGATTACCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10842.42 Da        Isoelectric Point: 5.6643

>AT108397 WP_136549875.1 NZ_CP031093:3422344-3422637 [Hydrocarboniclastica marina]
MTLHNPPHPGEFIREVYLEPFGISSRQLASSLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLAMQDMYDLWLA
RRTVDVDSLRPLDFEAA

Download         Length: 294 bp

>AT108397 NZ_CP031093:3422344-3422637 [Hydrocarboniclastica marina]
ATGACCTTGCATAATCCGCCGCATCCCGGTGAATTCATTCGGGAGGTGTACCTGGAACCTTTCGGCATCAGTTCCCGCCA
GCTTGCTTCCAGCCTTGGCGTCTCGCCCTCCACATTGTCACGACTACTCAAAGGAGACAGTGGCATCAGCCCGGAGATGT
CCCTGCGGCTGTCCAAGGTATTGGGTCGTACTCCGGAAAGTTGGCTGGCAATGCAGGATATGTATGATCTCTGGTTGGCG
CGAAGAACGGTCGATGTGGACAGTCTCCGGCCTCTTGATTTCGAAGCAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References