Detailed information of TA system TA108356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2693621..2694183
• Replicon: chromosome
• Accession: NZ_CP031057
• Organism: Acidipropionibacterium acidipropionici strain WGS7

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DUY81_RS12405
• Protein ID: WP_076692624.1
• Coordinates: 2693621..2693854 (+)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: A0A3Q9CPW7
• Locus tag: DUY81_RS12410
• Protein ID: WP_062820485.1
• Coordinates: 2693878..2694183 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DUY81_RS12385	2689046..2690179	-	1134	WP_062820489.1	glycosyltransferase	-
DUY81_RS12390	2690184..2690618	-	435	WP_062820488.1	RDD family protein	-
DUY81_RS12395	2690642..2691931	-	1290	WP_126132979.1	hypothetical protein	-
DUY81_RS12400	2692144..2693565	+	1422	WP_062820486.1	type I glutamate--ammonia ligase	-
DUY81_RS12405	2693621..2693854	+	234	WP_076692624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DUY81_RS12410	2693878..2694183	+	306	WP_062820485.1	HigA family addiction module antidote protein	Antitoxin
DUY81_RS12420	2694785..2695801	-	1017	WP_062820484.1	YdcF family protein	-
DUY81_RS12425	2695926..2696744	+	819	WP_015069929.1	Nif3-like dinuclear metal center hexameric protein	-
DUY81_RS12430	2696752..2698044	+	1293	WP_015069928.1	threonine/serine exporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (19-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-72)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8578.58 Da
• Isoelectric Point: 6.6970

>T108356 WP_076692624.1 NZ_CP031057:2693621-2693854 [Acidipropionibacterium acidipropionici]
IIRPCCQHFTNGSTGGLVRLLNAASELNSPRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWTDNGADDVEITDYH

Nucleotide

• Length: 234 bp

>T108356 NZ_CP031057:2693621-2693854 [Acidipropionibacterium acidipropionici]
ATCATCCGCCCGTGCTGCCAGCACTTCACCAACGGCAGCACGGGCGGACTCGTTCGCCTCCTCAACGCGGCCTCAGAACT
GAACAGCCCTCGGGTGCCGCCGGGAAATCGCTTGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCA
ACGACCAGTACCGAATCTGCTTCGTGTGGACCGACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11069.56 Da
• Isoelectric Point: 4.6135

>AT108356 WP_062820485.1 NZ_CP031057:2693878-2694183 [Acidipropionibacterium acidipropionici]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTAPRLSKALGVDDRFWINIQTDYD
LEVEGDLHADELAKVTTLVAS

Nucleotide

• Length: 306 bp

>AT108356 NZ_CP031057:2693878-2694183 [Acidipropionibacterium acidipropionici]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGCGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCCCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGGGAGACCTGCACGCCGACGAACTGGCCAAGGTGACCACCCTGGTCGCGAGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q9CPW7