Detailed information of TA system TA108353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 329293..329972
• Replicon: chromosome
• Accession: NZ_CP031057
• Organism: Acidipropionibacterium acidipropionici strain WGS7

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: DUY81_RS01465
• Protein ID: WP_099093033.1
• Coordinates: 329604..329972 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: -
• Locus tag: DUY81_RS01460
• Protein ID: WP_081685418.1
• Coordinates: 329293..329604 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DUY81_RS01425	324742..325599	+	858	WP_062819794.1	MFS transporter	-
DUY81_RS01430	325533..326054	+	522	WP_062819793.1	MFS transporter	-
DUY81_RS01435	326036..327328	-	1293	WP_062820775.1	ArsB/NhaD family transporter	-
DUY81_RS01440	327381..327830	-	450	WP_062819792.1	CBS domain-containing protein	-
DUY81_RS01445	328060..328326	+	267	WP_015068798.1	hypothetical protein	-
DUY81_RS01450	328448..328711	+	264	WP_015068797.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
DUY81_RS01455	328711..329130	+	420	WP_062819791.1	type II toxin-antitoxin system VapC family toxin	-
DUY81_RS01460	329293..329604	-	312	WP_081685418.1	helix-turn-helix domain-containing protein	Antitoxin
DUY81_RS01465	329604..329972	-	369	WP_099093033.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DUY81_RS01475	330365..331282	+	918	WP_082815990.1	SDR family oxidoreductase	-
DUY81_RS01480	331444..331761	+	318	WP_198401494.1	PadR family transcriptional regulator	-
DUY81_RS01485	331761..332168	+	408	WP_126133026.1	DUF1048 domain-containing protein	-
DUY81_RS01490	332165..332968	+	804	WP_062819788.1	ATP-binding cassette domain-containing protein	-
DUY81_RS01495	332965..333726	+	762	WP_062819787.1	ABC transporter permease	-
DUY81_RS01500	333744..334127	-	384	WP_015068789.1	D-ribose pyranase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-113)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13922.00 Da
• Isoelectric Point: 9.4797

>T108353 WP_099093033.1 NZ_CP031057:c329972-329604 [Acidipropionibacterium acidipropionici]
MVYTCGVWDIDAELIESWVGSLDEASRAQVIAALRILREAGPQLGRPLVDTVKASRYKNIKELRPGSSGRSELRILFAFD
PVRRAILLVAGDKAGDWERWYRKNIPRADDLYEQHLADLKRK

Nucleotide

• Length: 369 bp

>T108353 NZ_CP031057:c329972-329604 [Acidipropionibacterium acidipropionici]
ATGGTCTATACTTGTGGTGTGTGGGATATCGACGCCGAGCTCATCGAATCCTGGGTGGGTTCCCTGGATGAGGCGTCGCG
GGCTCAGGTGATCGCCGCTCTCCGGATTCTCCGGGAGGCGGGTCCGCAACTCGGCCGCCCTCTCGTCGACACGGTGAAGG
CGTCCCGCTACAAGAACATCAAGGAGTTGCGCCCGGGCTCATCGGGACGATCGGAACTGAGAATCCTGTTCGCCTTCGAT
CCTGTCCGCAGAGCCATCCTCCTGGTAGCCGGCGACAAGGCTGGCGACTGGGAGCGCTGGTACCGCAAGAACATCCCAAG
AGCCGATGACCTGTACGAGCAGCACCTCGCAGACCTGAAACGGAAGTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11627.24 Da
• Isoelectric Point: 7.0164

>AT108353 WP_081685418.1 NZ_CP031057:c329604-329293 [Acidipropionibacterium acidipropionici]
MTMSLSLEDLEKRYPVDERLVRAAEDQMRAEVRAYKLRELRERAGLTQAQLAERIGVGQRQVSKIEHGDLDSAKLGTIRR
YLQAVGGDLAVEYVAGDQRLQVA

Nucleotide

• Length: 312 bp

>AT108353 NZ_CP031057:c329604-329293 [Acidipropionibacterium acidipropionici]
ATGACGATGAGCCTGTCTCTGGAGGATCTGGAGAAGAGGTACCCGGTCGATGAGCGACTCGTCCGGGCCGCCGAGGATCA
GATGCGCGCCGAGGTCCGCGCCTACAAGCTCCGCGAACTGCGTGAGCGCGCCGGGCTCACCCAGGCCCAACTGGCGGAAC
GAATCGGCGTCGGACAGCGGCAGGTCTCCAAGATCGAACATGGCGACCTTGACAGCGCGAAACTCGGCACCATCCGCAGG
TACCTCCAAGCCGTCGGCGGTGACCTCGCCGTTGAGTACGTGGCTGGAGACCAGCGGCTACAAGTCGCCTGA