Detailed information of TA system TA108303

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 3283556..3284226
• Replicon: chromosome
• Accession: NZ_CP031009
• Organism: Alcanivorax sp. ALC70

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ASALC70_RS17480
• Protein ID: WP_161385024.1
• Coordinates: 3283556..3283918 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ASALC70_RS17485
• Protein ID: WP_161385025.1
• Coordinates: 3283915..3284226 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASALC70_RS17455	3278873..3279564	+	692	Protein_3447	FAD binding domain-containing protein	-
ASALC70_RS22260 (ASALC70_03551)	3279513..3279773	+	261	WP_281347038.1	hypothetical protein	-
ASALC70_RS17460 (ASALC70_03552)	3279777..3281977	+	2201	Protein_3449	aldehyde oxidoreductase molybdenum-binding subunit PaoC	-
ASALC70_RS17465 (ASALC70_03554)	3282042..3282368	+	327	WP_256244832.1	STN domain-containing protein	-
ASALC70_RS17470 (ASALC70_03555)	3282448..3282933	+	486	WP_260548384.1	DUF72 domain-containing protein	-
ASALC70_RS17475 (ASALC70_03556)	3282879..3283397	+	519	WP_260548385.1	DUF72 domain-containing protein	-
ASALC70_RS17480 (ASALC70_03557)	3283556..3283918	+	363	WP_161385024.1	toxin	Toxin
ASALC70_RS17485 (ASALC70_03558)	3283915..3284226	+	312	WP_161385025.1	transcriptional regulator	Antitoxin
ASALC70_RS17490 (ASALC70_03559)	3284341..3285093	+	753	WP_161385026.1	SDR family oxidoreductase	-
ASALC70_RS17495 (ASALC70_03560)	3285185..3285724	+	540	WP_161385027.1	hypothetical protein	-
ASALC70_RS17500 (ASALC70_03561)	3285741..3287147	-	1407	WP_260548386.1	carotenoid oxygenase family protein	-
ASALC70_RS17505 (ASALC70_03562)	3287329..3287931	+	603	WP_260548387.1	PAS domain-containing protein	-
ASALC70_RS17510	3287988..3288754	+	767	Protein_3459	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-100)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 14184.55 Da
• Isoelectric Point: 11.1775

>T108303 WP_161385024.1 NZ_CP031009:3283556-3283918 [Alcanivorax sp. ALC70]
MRAVFVELTPFRRHRAAYLDEDTYWLLQRVLMLHPEAGPRMPGTGGLRKLRFVDERRGKGTRGGLRVIYYWWPTGAQFWL
FTLYGKDEADDLTLAERRALRRLLKAELMARRKSDGRIMT

Nucleotide

• Length: 363 bp

>T108303 NZ_CP031009:3283556-3283918 [Alcanivorax sp. ALC70]
ATGCGAGCGGTATTCGTGGAGTTGACGCCGTTCCGGCGCCACCGGGCGGCGTATCTGGACGAGGACACCTACTGGCTGCT
GCAGCGGGTTCTGATGCTGCATCCGGAGGCTGGCCCCCGGATGCCGGGCACCGGCGGATTGCGCAAGCTGCGTTTCGTGG
ATGAACGGCGCGGCAAGGGCACGCGCGGCGGCTTACGGGTGATCTATTACTGGTGGCCCACGGGCGCTCAGTTCTGGTTG
TTCACGCTCTACGGCAAGGACGAGGCCGACGATTTGACGCTGGCCGAGCGTCGCGCGCTGAGACGCCTGCTGAAGGCGGA
GTTGATGGCGAGGCGTAAATCAGACGGGAGGATCATGACATGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11746.53 Da
• Isoelectric Point: 10.2869

>AT108303 WP_161385025.1 NZ_CP031009:3283915-3284226 [Alcanivorax sp. ALC70]
MKRDLFAELKEGFQELEAQRQGKLTLRGQEARLAPVAAIDAGDLLALRERLNLSRAVFAMYLRTNPRTLENWEQGRARPN
AQAATLIRLIERYPDTLERLAGL

Nucleotide

• Length: 312 bp

>AT108303 NZ_CP031009:3283915-3284226 [Alcanivorax sp. ALC70]
ATGAAGCGGGATCTGTTCGCGGAATTGAAGGAAGGCTTCCAGGAACTGGAGGCACAGCGCCAGGGCAAGCTCACCCTGCG
CGGCCAGGAAGCCCGGCTGGCGCCGGTGGCGGCCATCGACGCCGGCGACCTGCTGGCCCTGCGCGAGCGCCTCAATCTGT
CCCGGGCGGTGTTCGCCATGTATCTGCGCACCAACCCGCGCACCCTGGAGAACTGGGAGCAGGGCCGCGCCCGCCCCAAC
GCCCAGGCCGCCACTCTGATTCGTCTGATCGAACGCTACCCGGACACCCTGGAGCGCCTGGCCGGGCTGTAG