Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 432331..432938 Replicon chromosome
Accession NZ_CP031009
Organism Alcanivorax sp. ALC70

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ASALC70_RS02190 Protein ID WP_260549734.1
Coordinates 432331..432645 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASALC70_RS02195 Protein ID WP_161383753.1
Coordinates 432651..432938 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASALC70_RS02165 (ASALC70_00450) 427816..428511 + 696 WP_256245846.1 SIMPL domain-containing protein -
ASALC70_RS02170 (ASALC70_00451) 428520..429554 + 1035 WP_260549732.1 AraC family transcriptional regulator -
ASALC70_RS02175 (ASALC70_00452) 429702..431165 + 1464 WP_161383756.1 DUF3336 domain-containing protein -
ASALC70_RS02180 (ASALC70_00453) 431307..431945 + 639 WP_161383755.1 peroxiredoxin -
ASALC70_RS02190 (ASALC70_00455) 432331..432645 + 315 WP_260549734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASALC70_RS02195 (ASALC70_00456) 432651..432938 + 288 WP_161383753.1 NadS family protein Antitoxin
ASALC70_RS02200 433185..433970 + 786 Protein_435 DNA ligase -
ASALC70_RS02205 (ASALC70_00458) 434061..435026 - 966 WP_260549736.1 methyltransferase -
ASALC70_RS02210 (ASALC70_00459) 435182..435592 + 411 WP_260549737.1 hypothetical protein -
ASALC70_RS02215 (ASALC70_00460) 435870..437108 + 1239 WP_260549740.1 transglycosylase SLT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11721.51 Da        Isoelectric Point: 10.0241

>T108293 WP_260549734.1 NZ_CP031009:432331-432645 [Alcanivorax sp. ALC70]
MIFIETPVFTKRLRDLLDDESYAAFQQDLADSPKMGDVIQGTGGLRKVRVAASGRGKRGGARVIYYHFVSASQIALLLIY
PKNEKDDLSAAERKALKHIIEQWR

Download         Length: 315 bp

>T108293 NZ_CP031009:432331-432645 [Alcanivorax sp. ALC70]
ATGATCTTTATCGAGACCCCGGTATTCACCAAGCGCCTGCGTGATCTGCTTGATGACGAGAGTTACGCCGCCTTCCAGCA
GGATCTCGCCGACAGCCCCAAAATGGGTGACGTGATCCAGGGAACCGGCGGACTCCGCAAGGTACGGGTCGCCGCCAGTG
GGCGCGGGAAACGGGGCGGCGCACGGGTTATCTACTATCATTTCGTGTCGGCTTCACAGATCGCGTTACTGCTGATCTAT
CCGAAAAACGAAAAAGATGATCTGAGCGCGGCCGAGCGCAAGGCGCTCAAACACATTATCGAGCAATGGAGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10793.36 Da        Isoelectric Point: 8.8067

>AT108293 WP_161383753.1 NZ_CP031009:432651-432938 [Alcanivorax sp. ALC70]
MGKIFDDLMESVQQMDEIHRGERQPSREFTVDAMQVKAIRQTTGLSQAKFAKVIDVQLATLRNWEQGRREPTGPAKALLR
AIHKDPQHVIQALAD

Download         Length: 288 bp

>AT108293 NZ_CP031009:432651-432938 [Alcanivorax sp. ALC70]
ATGGGCAAAATCTTTGATGACCTCATGGAAAGCGTGCAGCAGATGGATGAAATCCACCGTGGTGAGCGTCAGCCTTCACG
GGAGTTCACCGTGGATGCAATGCAGGTGAAGGCTATCCGCCAGACAACCGGTCTCAGCCAGGCCAAGTTTGCCAAAGTGA
TCGACGTGCAACTTGCCACGCTCCGTAACTGGGAGCAGGGACGACGTGAACCAACGGGACCTGCCAAGGCATTGCTGCGG
GCGATTCACAAGGACCCCCAGCATGTTATCCAGGCATTGGCTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References