Detailed information of TA system TA108287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3930670..3931253
• Replicon: chromosome
• Accession: NZ_CP030980
• Organism: Yersinia enterocolitica subsp. palearctica strain Y1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7U7FJS5
• Locus tag: YEY1_RS18540
• Protein ID: WP_005162526.1
• Coordinates: 3930670..3930948 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: YEY1_RS18545
• Protein ID: WP_005162529.1
• Coordinates: 3930948..3931253 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YEY1_RS18520	3926151..3927098	-	948	WP_005162520.1	trehalose operon repressor TreR	-
YEY1_RS18535	3927870..3930590	+	2721	WP_005162523.1	magnesium-translocating P-type ATPase	-
YEY1_RS18540	3930670..3930948	+	279	WP_005162526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YEY1_RS18545	3930948..3931253	+	306	WP_005162529.1	HigA family addiction module antidote protein	Antitoxin
YEY1_RS18550	3931325..3933253	-	1929	WP_005162532.1	BglG family transcription antiterminator	-
YEY1_RS18555	3933326..3934567	-	1242	WP_005162536.1	lactonase family protein	-
YEY1_RS18560	3934697..3935437	-	741	Protein_3493	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10694.10 Da
• Isoelectric Point: 7.4011

>T108287 WP_005162526.1 NZ_CP030980:3930670-3930948 [Yersinia enterocolitica subsp. palearctica]
MIKSWKHKGLQRFFETGSAAGINPQHVKRIRDRLRFIDLAETIEDVNVAGYKLHPLQGEREGIWSVTVSGNWRITFEFTA
GDAFILNYEDYH

Nucleotide

• Length: 279 bp

>T108287 NZ_CP030980:3930670-3930948 [Yersinia enterocolitica subsp. palearctica]
ATGATAAAAAGTTGGAAACACAAAGGACTGCAACGCTTCTTTGAAACAGGTTCTGCCGCGGGCATTAATCCCCAGCATGT
TAAGCGAATTCGAGACCGCTTGCGATTTATCGACCTGGCGGAAACGATTGAGGATGTCAATGTTGCCGGATACAAGCTCC
ATCCGTTACAAGGTGAAAGAGAAGGGATCTGGTCAGTAACAGTAAGCGGAAATTGGCGCATTACATTCGAGTTTACCGCT
GGAGATGCGTTTATTCTTAACTACGAGGACTACCACTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10934.77 Da
• Isoelectric Point: 6.7158

>AT108287 WP_005162529.1 NZ_CP030980:3930948-3931253 [Yersinia enterocolitica subsp. palearctica]
MKMHNPPHPGEMIEGILEDLGLGIREFARALNVSPSTVQRLVACKAAISPEMAVKLAAVLGSTPAMWLRLQAAYDLGKAE
ENVDVSNLTKLYKPDPISLHS

Nucleotide

• Length: 306 bp

>AT108287 NZ_CP030980:3930948-3931253 [Yersinia enterocolitica subsp. palearctica]
ATGAAAATGCATAATCCCCCACATCCAGGGGAAATGATTGAAGGAATCCTCGAAGATTTGGGTCTAGGGATAAGGGAGTT
TGCCAGGGCATTAAACGTGTCACCTTCAACGGTACAACGGCTGGTTGCCTGTAAGGCGGCAATTTCACCGGAAATGGCGG
TAAAACTGGCCGCGGTTCTGGGAAGTACCCCAGCAATGTGGCTCCGCCTCCAGGCCGCTTATGACCTGGGAAAAGCAGAA
GAGAATGTTGATGTATCCAATCTGACTAAACTGTACAAACCGGATCCAATATCGCTGCATAGTTGA

Structures

Toxin

• AlphaFold DB: A0A7U7FJS5