Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 907449..908143 Replicon chromosome
Accession NZ_CP030980
Organism Yersinia enterocolitica subsp. palearctica strain Y1

Toxin (Protein)


Gene name mqsR Uniprot ID A0A7U7FJ92
Locus tag YEY1_RS04115 Protein ID WP_005166025.1
Coordinates 907449..907745 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A7U7IQA2
Locus tag YEY1_RS04120 Protein ID WP_005166024.1
Coordinates 907745..908143 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YEY1_RS04080 902922..904020 + 1099 WP_020282590.1 peptide chain release factor 2 -
YEY1_RS04085 904030..905547 + 1518 WP_005166031.1 lysine--tRNA ligase -
YEY1_RS04105 906604..906864 + 261 WP_005166028.1 type II toxin-antitoxin system RelE/ParE family toxin -
YEY1_RS04110 906930..907292 + 363 WP_005166026.1 helix-turn-helix domain-containing protein -
YEY1_RS04115 907449..907745 + 297 WP_005166025.1 type II toxin-antitoxin system MqsR family toxin Toxin
YEY1_RS04120 907745..908143 + 399 WP_005166024.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
YEY1_RS04125 908250..909452 - 1203 WP_005177049.1 IS256 family transposase -
YEY1_RS04130 909601..909801 - 201 WP_005166614.1 AlpA family transcriptional regulator -
YEY1_RS04135 909819..910655 + 837 Protein_776 Fic family protein -
YEY1_RS04140 911027..911407 + 381 WP_133964385.1 SgcJ/EcaC family oxidoreductase -
YEY1_RS04145 911505..912749 + 1245 WP_005166619.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11322.18 Da        Isoelectric Point: 7.7766

>T108276 WP_005166025.1 NZ_CP030980:907449-907745 [Yersinia enterocolitica subsp. palearctica]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL

Download         Length: 297 bp

>T108276 NZ_CP030980:907449-907745 [Yersinia enterocolitica subsp. palearctica]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14716.19 Da        Isoelectric Point: 8.8165

>AT108276 WP_005166024.1 NZ_CP030980:907745-908143 [Yersinia enterocolitica subsp. palearctica]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIR

Download         Length: 399 bp

>AT108276 NZ_CP030980:907745-908143 [Yersinia enterocolitica subsp. palearctica]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTACTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FJ92

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7IQA2

References