Detailed information of TA system TA108238

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-SR6/-
• Location: 2278844..2279008
• Replicon: chromosome
• Accession: NZ_CP030937
• Organism: Bacillus sp. DM2

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: DS740_RS22750
• Protein ID: WP_009967548.1
• Coordinates: 2278844..2278960 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	SR6
Locus tag	-
Coordinates	2278955..2279008 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DS740_RS11730	2273962..2274354	+	393	WP_010328137.1	hypothetical protein	-
DS740_RS11735	2274375..2274626	+	252	WP_114168631.1	phage holin	-
DS740_RS11740	2274753..2275889	+	1137	WP_114168633.1	tetratricopeptide repeat protein	-
DS740_RS11745	2275879..2276055	+	177	WP_019712878.1	hypothetical protein	-
DS740_RS11750	2276096..2277346	-	1251	WP_114168635.1	UV damage repair protein UvrX	-
DS740_RS11755	2277339..2277671	-	333	WP_114168637.1	YolD-like family protein	-
DS740_RS11760	2277845..2278180	+	336	WP_041054825.1	hypothetical protein	-
DS740_RS11765	2278224..2278583	-	360	WP_041338710.1	hypothetical protein	-
DS740_RS22750	2278844..2278960	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
-	2278955..2279008	-	54	NuclAT_2	-	Antitoxin
-	2278955..2279008	-	54	NuclAT_2	-	Antitoxin
-	2278955..2279008	-	54	NuclAT_2	-	Antitoxin
-	2278955..2279008	-	54	NuclAT_2	-	Antitoxin
DS740_RS11770	2279052..2279510	-	459	WP_109962768.1	SMI1/KNR4 family protein	-
DS740_RS11775	2279523..2281409	-	1887	WP_109962769.1	HNH endonuclease	-
DS740_RS11780	2281542..2282075	-	534	WP_109962770.1	SMI1/KNR4 family protein	-
DS740_RS11785	2282160..2282410	-	251	Protein_2257	hypothetical protein	-
DS740_RS11790	2282590..2283474	+	885	WP_109962771.1	endonuclease YokF	-
DS740_RS11795	2283517..2283990	-	474	WP_109962772.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2163700..2286801	123101

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T108238 WP_009967548.1 NZ_CP030937:2278844-2278960 [Bacillus sp. DM2]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T108238 NZ_CP030937:2278844-2278960 [Bacillus sp. DM2]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin

Nucleotide

• Length: 54 bp

>AT108238 NZ_CP030937:c2279008-2278955 [Bacillus sp. DM2]
AAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAAACTCAAGGGAAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin