Detailed information of TA system TA108224

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2911019..2911527
• Replicon: chromosome
• Accession: NZ_CP030930
• Organism: Streptomyces cavourensis strain TJ430

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: N0CS17
• Locus tag: DTW94_RS12710
• Protein ID: WP_015609077.1
• Coordinates: 2911267..2911527 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: DTW94_RS12705
• Protein ID: WP_114931509.1
• Coordinates: 2911019..2911270 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DTW94_RS12695	2906765..2908756	-	1992	WP_205387625.1	PQQ-binding-like beta-propeller repeat protein	-
DTW94_RS12700	2909062..2910885	-	1824	WP_114931508.1	ABC-F family ATP-binding cassette domain-containing protein	-
DTW94_RS12705	2911019..2911270	+	252	WP_114931509.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DTW94_RS12710	2911267..2911527	+	261	WP_015609077.1	Txe/YoeB family addiction module toxin	Toxin
DTW94_RS12715	2911515..2912960	-	1446	WP_114931510.1	acyltransferase family protein	-
DTW94_RS12720	2913207..2913950	+	744	WP_114931511.1	hypothetical protein	-
DTW94_RS12725	2913989..2914579	-	591	WP_114934097.1	XRE family transcriptional regulator	-
DTW94_RS12730	2914768..2915496	+	729	WP_114931512.1	class I SAM-dependent methyltransferase	-
DTW94_RS12735	2915538..2916038	+	501	WP_114931513.1	DinB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10452.79 Da
• Isoelectric Point: 9.4245

>T108224 WP_015609077.1 NZ_CP030930:2911267-2911527 [Streptomyces cavourensis]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRVAAC
RYHYGR

Nucleotide

• Length: 261 bp

>T108224 NZ_CP030930:2911267-2911527 [Streptomyces cavourensis]
GTGAAGTTCGTATGGGATCAGTCGTCCTGGGACGACTACGTCTGGTGGCAGAACCAGGACCGCAAGATCCTCAAGCGGAT
CAACACGCTGCTCCAGGACATCGCCCGGAACGGCAACGAGGGCATGGGCAAGCCGGAGCCCCTGAAGCACGGATTCCAGG
GGTACTGGTCGCGCCGCATCACCGATGAGCACCGGCTCATCTACAAGGTGGTCGACGACGAGGTGCGTGTCGCCGCCTGC
CGCTACCACTACGGGCGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9313.44 Da
• Isoelectric Point: 4.6892

>AT108224 WP_114931509.1 NZ_CP030930:2911019-2911270 [Streptomyces cavourensis]
MRTMTYTESRAKYAETLSAVVNDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIERLESGGGTVRE
LAE

Nucleotide

• Length: 252 bp

>AT108224 NZ_CP030930:2911019-2911270 [Streptomyces cavourensis]
ATGCGCACGATGACCTACACCGAGTCGCGGGCGAAGTACGCGGAAACCCTGAGCGCGGTCGTGAACGACCGCGAGGAGGT
CGTGGTCACGCGGGCGGGCCATGAGCCCGTGGTGATAGTGGCGCTCGACGAGTACGAGTCGCTCAAGGAGACCGCGTACC
AGCTCCGCAGCCCGGAGAACGCCCGTCGGCTGCTGGCCTCGATCGAGCGCCTGGAGAGCGGGGGCGGCACGGTGCGGGAG
CTGGCGGAGTGA

Structures

Toxin

• AlphaFold DB: N0CS17