Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3020669..3021362 Replicon chromosome
Accession NZ_CP030919
Organism Escherichia coli strain KL53

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag CPT07_RS15910 Protein ID WP_000415584.1
Coordinates 3021066..3021362 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag CPT07_RS15905 Protein ID WP_000650107.1
Coordinates 3020669..3021064 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPT07_RS15890 3016533..3018791 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
CPT07_RS15895 3018929..3020536 - 1608 Protein_2904 ABC transporter substrate-binding protein -
CPT07_RS15905 3020669..3021064 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
CPT07_RS15910 3021066..3021362 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
CPT07_RS15915 3021567..3021992 - 426 WP_044864279.1 GyrI-like domain-containing protein -
CPT07_RS15920 3022083..3023296 + 1214 WP_139371347.1 IS3 family transposase -
CPT07_RS15925 3023415..3023807 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
CPT07_RS15930 3023959..3024618 + 660 WP_001221502.1 two-component system response regulator QseB -
CPT07_RS15935 3024615..3025964 + 1350 WP_000673354.1 two-component system sensor histidine kinase QseC -
CPT07_RS15940 3026010..3026342 - 333 WP_000914691.1 DUF2645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T108191 WP_000415584.1 NZ_CP030919:c3021362-3021066 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T108191 NZ_CP030919:c3021362-3021066 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT108191 WP_000650107.1 NZ_CP030919:c3021064-3020669 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT108191 NZ_CP030919:c3021064-3020669 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References