Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2675635..2676137 | Replicon | chromosome |
Accession | NZ_CP030911 | ||
Organism | Pseudomonas aeruginosa strain Y71 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A1C7CBF7 |
Locus tag | Ysp71_RS12970 | Protein ID | WP_023081358.1 |
Coordinates | 2675883..2676137 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A1C7C600 |
Locus tag | Ysp71_RS12965 | Protein ID | WP_004350479.1 |
Coordinates | 2675635..2675886 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
Ysp71_RS12940 | 2670747..2671391 | + | 645 | WP_003090351.1 | UvrY/SirA/GacA family response regulator transcription factor | - |
Ysp71_RS12945 | 2671392..2673218 | + | 1827 | WP_003097551.1 | excinuclease ABC subunit UvrC | - |
Ysp71_RS12950 | 2673252..2673812 | + | 561 | WP_003090349.1 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | - |
Ysp71_RS12960 | 2674180..2675550 | + | 1371 | WP_023081359.1 | tyrosine-type recombinase/integrase | - |
Ysp71_RS12965 | 2675635..2675886 | + | 252 | WP_004350479.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
Ysp71_RS12970 | 2675883..2676137 | + | 255 | WP_023081358.1 | Txe/YoeB family addiction module toxin | Toxin |
Ysp71_RS12975 | 2676363..2676758 | + | 396 | WP_023081357.1 | DUF3742 family protein | - |
Ysp71_RS12980 | 2676766..2678286 | - | 1521 | WP_004350477.1 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
Ysp71_RS12985 | 2678301..2678651 | - | 351 | WP_023081356.1 | hypothetical protein | - |
Ysp71_RS12990 | 2678839..2679702 | - | 864 | WP_004350470.1 | integrase domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10061.50 Da Isoelectric Point: 8.4789
>T108149 WP_023081358.1 NZ_CP030911:2675883-2676137 [Pseudomonas aeruginosa]
VKLIWSEQAWDDYLYWQDTDKRMVKKVNELIKDACRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDDALLIAAC
RYHY
VKLIWSEQAWDDYLYWQDTDKRMVKKVNELIKDACRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDDALLIAAC
RYHY
Download Length: 255 bp
>T108149 NZ_CP030911:2675883-2676137 [Pseudomonas aeruginosa]
GTGAAGCTGATCTGGTCGGAACAAGCCTGGGACGATTATCTGTACTGGCAGGACACGGATAAGCGTATGGTGAAAAAGGT
CAACGAGTTGATCAAGGATGCCTGCCGTACCCCGTTCGAGGGCAAGGGCAAGCCGGAGCCGCTTCGCCACAACCTGGCGG
GCTTCTGGTCGAGACGGATCACGGCCGAGCATCGGTTTGTGTATTCGGTGACGGATGACGCGCTGCTGATTGCAGCCTGC
CGTTACCACTATTGA
GTGAAGCTGATCTGGTCGGAACAAGCCTGGGACGATTATCTGTACTGGCAGGACACGGATAAGCGTATGGTGAAAAAGGT
CAACGAGTTGATCAAGGATGCCTGCCGTACCCCGTTCGAGGGCAAGGGCAAGCCGGAGCCGCTTCGCCACAACCTGGCGG
GCTTCTGGTCGAGACGGATCACGGCCGAGCATCGGTTTGTGTATTCGGTGACGGATGACGCGCTGCTGATTGCAGCCTGC
CGTTACCACTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9363.65 Da Isoelectric Point: 4.5843
>AT108149 WP_004350479.1 NZ_CP030911:2675635-2675886 [Pseudomonas aeruginosa]
MRTISYTEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEFNALEETAYLLRSPANARRLMDSIDSLKQGQGVERD
LAE
MRTISYTEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEFNALEETAYLLRSPANARRLMDSIDSLKQGQGVERD
LAE
Download Length: 252 bp
>AT108149 NZ_CP030911:2675635-2675886 [Pseudomonas aeruginosa]
ATGCGCACGATCAGTTACACCGAAGCCCGGCAGAACCTGTCGGCCACCATGATGAAGACCGTGGAGGATCGCGCCCCGAT
CCTGATTACCCGGCAGAACGGCGAAGCCTGCGTGTTGATGTCCCTGGAAGAGTTCAACGCGCTGGAGGAAACGGCTTATC
TGCTGCGCTCCCCGGCCAATGCCCGCCGCCTGATGGATTCGATTGACAGCCTCAAGCAAGGCCAGGGCGTCGAGCGGGAT
TTGGCCGAGTGA
ATGCGCACGATCAGTTACACCGAAGCCCGGCAGAACCTGTCGGCCACCATGATGAAGACCGTGGAGGATCGCGCCCCGAT
CCTGATTACCCGGCAGAACGGCGAAGCCTGCGTGTTGATGTCCCTGGAAGAGTTCAACGCGCTGGAGGAAACGGCTTATC
TGCTGCGCTCCCCGGCCAATGCCCGCCGCCTGATGGATTCGATTGACAGCCTCAAGCAAGGCCAGGGCGTCGAGCGGGAT
TTGGCCGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1C7CBF7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1C7C600 |