Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5768975..5769570 Replicon chromosome
Accession NZ_CP030910
Organism Pseudomonas aeruginosa strain Y31

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Y31_RS27515 Protein ID WP_115759797.1
Coordinates 5769292..5769570 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Y31_RS27510 Protein ID WP_003099268.1
Coordinates 5768975..5769280 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y31_RS27475 5764428..5764718 - 291 WP_023083237.1 DUF5447 family protein -
Y31_RS27485 5764930..5765202 - 273 WP_003115921.1 hypothetical protein -
Y31_RS27490 5765312..5765578 + 267 WP_016852153.1 hypothetical protein -
Y31_RS27495 5765701..5766546 + 846 WP_196645791.1 helix-turn-helix domain-containing protein -
Y31_RS27500 5766521..5768059 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
Y31_RS27505 5768071..5768598 - 528 WP_071535723.1 AAA family ATPase -
Y31_RS27510 5768975..5769280 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
Y31_RS27515 5769292..5769570 - 279 WP_115759797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Y31_RS27525 5769899..5772127 + 2229 WP_031633241.1 TonB-dependent receptor -
Y31_RS27530 5772197..5772844 - 648 WP_003095021.1 carbonate dehydratase -
Y31_RS27535 5772906..5774144 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T108145 WP_115759797.1 NZ_CP030910:c5769570-5769292 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSITINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T108145 NZ_CP030910:c5769570-5769292 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCACGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT108145 WP_003099268.1 NZ_CP030910:c5769280-5768975 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT108145 NZ_CP030910:c5769280-5768975 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References