Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
Location | 5768975..5769570 | Replicon | chromosome |
Accession | NZ_CP030910 | ||
Organism | Pseudomonas aeruginosa strain Y31 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | Y31_RS27515 | Protein ID | WP_115759797.1 |
Coordinates | 5769292..5769570 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | Y31_RS27510 | Protein ID | WP_003099268.1 |
Coordinates | 5768975..5769280 (-) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
Y31_RS27475 | 5764428..5764718 | - | 291 | WP_023083237.1 | DUF5447 family protein | - |
Y31_RS27485 | 5764930..5765202 | - | 273 | WP_003115921.1 | hypothetical protein | - |
Y31_RS27490 | 5765312..5765578 | + | 267 | WP_016852153.1 | hypothetical protein | - |
Y31_RS27495 | 5765701..5766546 | + | 846 | WP_196645791.1 | helix-turn-helix domain-containing protein | - |
Y31_RS27500 | 5766521..5768059 | + | 1539 | WP_023082696.1 | GNAT family N-acetyltransferase | - |
Y31_RS27505 | 5768071..5768598 | - | 528 | WP_071535723.1 | AAA family ATPase | - |
Y31_RS27510 | 5768975..5769280 | - | 306 | WP_003099268.1 | HigA family addiction module antidote protein | Antitoxin |
Y31_RS27515 | 5769292..5769570 | - | 279 | WP_115759797.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
Y31_RS27525 | 5769899..5772127 | + | 2229 | WP_031633241.1 | TonB-dependent receptor | - |
Y31_RS27530 | 5772197..5772844 | - | 648 | WP_003095021.1 | carbonate dehydratase | - |
Y31_RS27535 | 5772906..5774144 | - | 1239 | WP_003111578.1 | C69 family dipeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10646.19 Da Isoelectric Point: 7.8937
>T108145 WP_115759797.1 NZ_CP030910:c5769570-5769292 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSITINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSITINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
>T108145 NZ_CP030910:c5769570-5769292 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCACGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCACGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11213.79 Da Isoelectric Point: 5.0747
>AT108145 WP_003099268.1 NZ_CP030910:c5769280-5768975 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG
Download Length: 306 bp
>AT108145 NZ_CP030910:c5769280-5768975 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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