Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1452241..1452826 Replicon chromosome
Accession NZ_CP030880
Organism Acinetobacter haemolyticus strain HW-2A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DS737_RS06610 Protein ID WP_113997133.1
Coordinates 1452506..1452826 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DS737_RS06605 Protein ID WP_005082538.1
Coordinates 1452241..1452513 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DS737_RS06585 1448263..1448763 + 501 WP_113997971.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
DS737_RS06590 1448763..1449098 + 336 WP_005082534.1 hydroxyisourate hydrolase -
DS737_RS06595 1449146..1450522 + 1377 WP_113997131.1 purine permease -
DS737_RS06600 1450705..1452000 + 1296 WP_113997132.1 hypothetical protein -
DS737_RS06605 1452241..1452513 - 273 WP_005082538.1 helix-turn-helix domain-containing protein Antitoxin
DS737_RS06610 1452506..1452826 - 321 WP_113997133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DS737_RS06615 1453010..1454167 - 1158 WP_113997134.1 FAD-dependent urate hydroxylase HpxO -
DS737_RS06620 1454349..1455059 - 711 WP_005082543.1 FadR family transcriptional regulator -
DS737_RS06625 1455226..1456230 + 1005 WP_113997135.1 allantoicase -
DS737_RS06630 1456476..1456979 + 504 WP_113997136.1 ureidoglycolate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(17-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12167.13 Da        Isoelectric Point: 7.8145

>T108137 WP_113997133.1 NZ_CP030880:c1452826-1452506 [Acinetobacter haemolyticus]
MLFIETSIFTKQIKELISDDEYRELQQELLVQPDKGDLIKNGGGIRKVRCAQGSKGKSGGIRVIYYWITKDDQIFMLLAY
PKSVKENLTEKETAILCQLVKEQFHG

Download         Length: 321 bp

>T108137 NZ_CP030880:c1452826-1452506 [Acinetobacter haemolyticus]
ATGCTATTTATTGAAACCAGTATTTTTACCAAACAAATCAAAGAGCTTATCTCTGATGATGAATATAGAGAACTCCAACA
AGAACTTTTAGTTCAGCCAGATAAGGGAGATCTCATTAAAAATGGTGGTGGAATTCGTAAAGTACGTTGTGCCCAAGGCA
GTAAAGGAAAAAGTGGTGGCATTCGAGTAATTTATTACTGGATCACTAAAGATGATCAAATATTTATGCTATTGGCTTAC
CCTAAATCTGTTAAAGAAAACCTAACTGAGAAAGAGACCGCTATCCTATGTCAACTTGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10094.53 Da        Isoelectric Point: 8.6797

>AT108137 WP_005082538.1 NZ_CP030880:c1452513-1452241 [Acinetobacter haemolyticus]
MDNNLFDDLVASIKEAGAIKRNEVKASRVTELTLPDIKEVREKTGLSQTEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT108137 NZ_CP030880:c1452513-1452241 [Acinetobacter haemolyticus]
ATGGATAATAACTTATTTGATGACCTCGTTGCTTCGATCAAAGAAGCAGGAGCTATTAAACGTAATGAAGTTAAAGCAAG
TCGAGTGACCGAGCTGACTCTTCCTGATATTAAAGAAGTTCGTGAGAAAACAGGATTGAGCCAAACAGAATTTGCTGCAC
GTTTGCATATTAGCCCTCGTACACTTCAGAACTGGGAACAAGGCAGACGCTATCCAACAGGGCCAGCAGCAACCCTGATT
CGCATTCTAGATGCACATCCGAGCCTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References