Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1021842..1022542 Replicon chromosome
Accession NZ_CP030865
Organism Micromonospora sp. B006

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag MicB006_RS05020 Protein ID WP_116504150.1
Coordinates 1021842..1022234 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MicB006_RS05025 Protein ID WP_013284175.1
Coordinates 1022231..1022542 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MicB006_RS05000 1017377..1018171 + 795 WP_091420164.1 ABC transporter permease -
MicB006_RS05005 1018168..1019589 + 1422 WP_116504145.1 FAD-binding oxidoreductase -
MicB006_RS05010 1019589..1020791 + 1203 WP_116504147.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
MicB006_RS05015 1020788..1021801 + 1014 WP_116504148.1 agmatinase -
MicB006_RS05020 1021842..1022234 + 393 WP_116504150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MicB006_RS05025 1022231..1022542 + 312 WP_013284175.1 helix-turn-helix transcriptional regulator Antitoxin
MicB006_RS05030 1022562..1023005 - 444 WP_116504152.1 hypothetical protein -
MicB006_RS05035 1023140..1023487 - 348 WP_073824767.1 DUF779 domain-containing protein -
MicB006_RS05040 1023487..1024992 - 1506 WP_116504154.1 aldehyde dehydrogenase family protein -
MicB006_RS05045 1025033..1026313 - 1281 WP_116504155.1 transcriptional regulator -
MicB006_RS05050 1026550..1027215 + 666 WP_116504157.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-117)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-91)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14803.77 Da        Isoelectric Point: 10.5017

>T108109 WP_116504150.1 NZ_CP030865:1021842-1022234 [Micromonospora sp. B006]
MGADGKRWSVRVTGEVRHWLRDLRDHDPASYESVRVAVDKLAEVGPGLGRPLVDTLRGSSLRNLKELRPRSGRDVALRVL
FVFDPWSQAVLLVAGNKAGDWSRWYRQHIPAAEVAYKAWLDSERERRGES

Download         Length: 393 bp

>T108109 NZ_CP030865:1021842-1022234 [Micromonospora sp. B006]
ATGGGTGCGGACGGGAAGCGCTGGTCGGTCCGGGTCACCGGAGAGGTCCGGCACTGGCTGCGCGACCTGCGGGACCACGA
CCCGGCGTCGTACGAGAGCGTCCGGGTGGCGGTGGACAAGCTGGCCGAGGTCGGGCCAGGGCTGGGCCGCCCGCTCGTGG
ACACGCTGCGCGGGAGCAGCCTCCGTAATCTGAAGGAGCTGCGGCCCCGCTCCGGTCGGGACGTGGCGCTCCGGGTGCTG
TTCGTCTTCGATCCGTGGTCGCAGGCGGTCCTCCTGGTCGCCGGCAACAAGGCAGGCGACTGGAGTCGCTGGTACCGGCA
GCACATCCCGGCGGCGGAGGTTGCCTACAAGGCTTGGCTCGACAGCGAGCGCGAGCGAAGGGGGGAGTCGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11668.90 Da        Isoelectric Point: 4.3953

>AT108109 WP_013284175.1 NZ_CP030865:1022231-1022542 [Micromonospora sp. B006]
VTEFYHWDEVRAELGGDDEAYEAERARTDAWVSAFHLAEERKRLGLTQRQVAEIMGVTPGRVSQIENGDLDVNEVATLSR
YANALGARLRIIFDYGDDLRQIA

Download         Length: 312 bp

>AT108109 NZ_CP030865:1022231-1022542 [Micromonospora sp. B006]
GTGACGGAGTTCTATCACTGGGACGAGGTCCGCGCCGAACTCGGCGGCGACGACGAGGCGTACGAGGCGGAGCGCGCCCG
GACCGACGCGTGGGTGAGCGCGTTCCACCTGGCCGAGGAGCGCAAGCGGCTGGGGCTCACCCAGCGGCAGGTTGCCGAGA
TCATGGGCGTGACGCCCGGCCGGGTGAGCCAGATTGAGAACGGCGACCTCGACGTCAACGAGGTGGCAACGCTGAGCCGC
TATGCCAACGCCCTCGGCGCCCGGCTGCGGATCATCTTCGACTACGGCGACGACCTCCGGCAGATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References