Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 847795..848492 Replicon chromosome
Accession NZ_CP030865
Organism Micromonospora sp. B006

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MicB006_RS04245 Protein ID WP_116503955.1
Coordinates 848124..848492 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MicB006_RS04240 Protein ID WP_116503954.1
Coordinates 847795..848127 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MicB006_RS04215 843173..843913 + 741 WP_073825157.1 hypothetical protein -
MicB006_RS04220 843956..844918 + 963 WP_073825154.1 GNAT family N-acetyltransferase -
MicB006_RS04225 844993..845448 - 456 WP_030501227.1 gamma-glutamylcyclotransferase -
MicB006_RS04230 845614..847017 + 1404 WP_116503950.1 NAD(P)H-quinone dehydrogenase -
MicB006_RS04235 847044..847697 - 654 WP_116503952.1 DUF998 domain-containing protein -
MicB006_RS04240 847795..848127 - 333 WP_116503954.1 helix-turn-helix domain-containing protein Antitoxin
MicB006_RS04245 848124..848492 - 369 WP_116503955.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MicB006_RS04250 848549..849172 - 624 WP_116511161.1 DedA family protein -
MicB006_RS04255 849669..850886 + 1218 WP_116503957.1 threonine--tRNA ligase -
MicB006_RS04260 850957..853011 - 2055 WP_116503959.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-97)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13907.76 Da        Isoelectric Point: 4.9676

>T108108 WP_116503955.1 NZ_CP030865:c848492-848124 [Micromonospora sp. B006]
VWEIRLHPEVERWFLDLCSSEPSTADLVSEALDLLAEHGPALGRPLVDRLKGSAYHHMKELRPGSSGTSEVRMIFAFDPS
REAIFLVAGDKAGQWQSWYRLAIPLADERFQEHLINLKEEQP

Download         Length: 369 bp

>T108108 NZ_CP030865:c848492-848124 [Micromonospora sp. B006]
GTGTGGGAGATCAGGCTTCATCCGGAGGTCGAGCGTTGGTTCCTGGACCTGTGCTCGAGTGAGCCGAGCACCGCTGACCT
CGTCAGCGAAGCGCTCGACCTACTGGCAGAGCACGGCCCCGCACTGGGTCGGCCACTGGTTGACCGACTCAAGGGCAGCG
CTTATCACCACATGAAGGAACTACGACCAGGTTCCAGCGGCACCTCGGAGGTTCGGATGATCTTCGCGTTCGATCCCTCC
CGGGAAGCCATCTTCCTGGTGGCCGGGGACAAGGCGGGGCAGTGGCAGAGTTGGTACCGGCTCGCCATTCCGTTGGCGGA
CGAGCGGTTCCAGGAGCACCTGATCAACCTGAAGGAAGAACAGCCATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11910.49 Da        Isoelectric Point: 10.0730

>AT108108 WP_116503954.1 NZ_CP030865:c848127-847795 [Micromonospora sp. B006]
MSGGANWRDVKAKARRVDPSWDDSERVARRGQLREQMLASVSGAQLAEIRKQLGMTQAQLADAAGLSQARISQIENGESV
NLEILRAYVTGLGGHLDVVARIGNIRLDVA

Download         Length: 333 bp

>AT108108 NZ_CP030865:c848127-847795 [Micromonospora sp. B006]
ATGAGTGGTGGGGCGAACTGGCGCGACGTCAAGGCGAAGGCCCGCAGAGTGGATCCCTCGTGGGACGACAGCGAGCGTGT
CGCCCGGCGGGGACAGTTGCGAGAGCAGATGCTGGCTTCGGTCAGCGGCGCGCAGCTGGCGGAGATCCGCAAGCAGCTGG
GCATGACCCAGGCTCAGCTGGCGGACGCGGCGGGCTTGTCTCAGGCGCGGATCAGCCAGATCGAGAACGGCGAGAGCGTC
AACCTGGAGATTCTGCGCGCCTATGTGACCGGACTCGGCGGACACCTTGATGTGGTCGCCCGGATCGGGAACATTCGTCT
CGACGTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References