108093

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2096199..2097472 Replicon chromosome
Accession NZ_CP030850
Organism Runella sp. HYN0085

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag DR864_RS08975 Protein ID WP_114066640.1
Coordinates 2096528..2097472 (+) Length 315 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag DR864_RS08970 Protein ID WP_114066639.1
Coordinates 2096199..2096531 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR864_RS08955 2092390..2094042 - 1653 WP_114070220.1 hypothetical protein -
DR864_RS08960 2094602..2095822 + 1221 WP_114066637.1 site-specific integrase -
DR864_RS08965 2095991..2096212 + 222 WP_114066638.1 helix-turn-helix transcriptional regulator -
DR864_RS08970 2096199..2096531 + 333 WP_114066639.1 HipA N-terminal domain-containing protein Antitoxin
DR864_RS08975 2096528..2097472 + 945 WP_114066640.1 HipA domain-containing protein Toxin
DR864_RS08980 2097721..2098662 + 942 WP_162793666.1 hypothetical protein -
DR864_RS08985 2098782..2099105 + 324 WP_114066642.1 helix-turn-helix domain-containing protein -
DR864_RS08990 2099102..2099458 + 357 WP_114066643.1 hypothetical protein -
DR864_RS08995 2099455..2100618 + 1164 WP_114066644.1 hypothetical protein -
DR864_RS09000 2100689..2100868 + 180 WP_114066645.1 DUF4248 domain-containing protein -
DR864_RS09005 2100981..2101424 + 444 WP_114066646.1 hypothetical protein -
DR864_RS09010 2101430..2101642 + 213 WP_114066647.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(55-284)

Antitoxin

HipA, N-terminal subdomain 1

(4-102)


Sequences

Toxin        


Download         Length: 315 a.a.        Molecular weight: 35797.61 Da        Isoelectric Point: 9.3273

>T108093 WP_114066640.1 NZ_CP030850:2096528-2097472 [Runella sp. HYN0085]
MKRCLYCYQLLGPTETDFHASCSKKIFGNATPPALPYTENQMEELATQVIRSQMTVTGVQPKLSLEIVSGKKKTESQRFT
IVGLWGGYILKPPTPHYPQLPEVEDLTMHLAEIAGIRTVPHSLIRLQSGSLAYITKRIDRVKKNKLPMEDMCQLTERLTE
DKYHGSYEQIAKTILKYSTNPGLDTVNFFEQVLFSFLTGNADMHLKNFSLITQPSLGPILSPAYDMVATALVNPADNEDM
ALTLNGKKRKLKRSDFTTAFTTLKLEVKQQENIFKKMEKVKEKWMEYIAISFLSPDFKEAFIQLIQERFSRLKA

Download         Length: 945 bp

>T108093 NZ_CP030850:2096528-2097472 [Runella sp. HYN0085]
ATGAAAAGGTGTTTGTACTGTTATCAACTTTTGGGGCCAACGGAAACCGATTTTCATGCTTCGTGCAGTAAAAAAATCTT
TGGCAACGCTACTCCCCCCGCTCTGCCCTATACCGAAAATCAAATGGAAGAATTGGCTACCCAAGTCATAAGAAGCCAAA
TGACCGTCACGGGAGTCCAGCCAAAACTGTCTTTGGAAATTGTCTCAGGAAAAAAGAAAACAGAATCTCAACGGTTTACG
ATTGTGGGGCTTTGGGGAGGGTATATCTTAAAACCCCCAACCCCGCATTATCCACAATTACCTGAAGTAGAGGACTTAAC
CATGCACCTGGCTGAAATCGCCGGAATCAGGACCGTACCCCATAGCCTGATTCGTCTGCAATCGGGTAGTTTGGCCTATA
TTACCAAACGAATAGACCGGGTAAAAAAAAACAAATTACCCATGGAAGACATGTGTCAACTGACGGAGCGGCTGACAGAA
GATAAATACCACGGTTCGTATGAACAAATAGCGAAAACCATCCTGAAATATTCAACCAATCCGGGCTTAGATACCGTCAA
TTTTTTTGAGCAGGTACTATTTTCATTTCTTACAGGCAATGCCGATATGCACCTGAAAAATTTTTCACTGATTACCCAAC
CCAGCCTCGGGCCGATACTGTCCCCTGCCTACGACATGGTAGCTACGGCCTTGGTCAATCCAGCTGATAACGAAGATATG
GCGCTGACTCTCAATGGGAAAAAGAGAAAATTAAAGCGCAGCGACTTTACCACAGCGTTTACCACCTTAAAATTGGAGGT
AAAACAACAGGAAAATATTTTCAAAAAAATGGAAAAAGTAAAAGAGAAATGGATGGAGTATATAGCCATCAGTTTTCTCA
GTCCTGATTTTAAAGAAGCCTTTATCCAATTGATTCAGGAAAGATTTTCCAGATTAAAGGCATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12870.82 Da        Isoelectric Point: 4.7132

>AT108093 WP_114066639.1 NZ_CP030850:2096199-2096531 [Runella sp. HYN0085]
MRKAEVKFHALTAGWLIQDENGYHFEYDKDYLQREKPEPISLTLPLQQVAFTDKVLFPFFDGLIPEGWLLDIAQRNWKLN
PRDRMGLLLACCRDCIGAVSIYPVEEEDRL

Download         Length: 333 bp

>AT108093 NZ_CP030850:2096199-2096531 [Runella sp. HYN0085]
ATGAGAAAGGCTGAAGTCAAATTCCACGCTTTAACCGCAGGGTGGCTGATACAGGATGAAAACGGGTATCATTTTGAATA
TGACAAGGATTATTTGCAGAGAGAAAAACCCGAACCGATCAGCCTTACGCTGCCCTTACAACAGGTTGCTTTTACCGATA
AAGTATTGTTCCCCTTCTTCGACGGCCTGATTCCTGAAGGATGGCTGCTGGACATTGCCCAAAGAAACTGGAAACTCAAT
CCTCGTGATCGAATGGGATTATTACTGGCTTGTTGCAGAGATTGTATTGGAGCGGTAAGTATATACCCTGTTGAAGAGGA
GGATAGACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References