Detailed information of TA system TA108086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 715882..716479
• Replicon: chromosome
• Accession: NZ_CP030826
• Organism: Neisseria meningitidis strain 11-251

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: DRA65_RS03765
• Protein ID: WP_002242826.1
• Coordinates: 716201..716479 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DRA65_RS03760
• Protein ID: WP_002221020.1
• Coordinates: 715882..716193 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRA65_RS03740	711775..711939	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
DRA65_RS03745	711939..712550	+	612	WP_042744707.1	baseplate J/gp47 family protein	-
DRA65_RS03750	712547..713107	+	561	WP_002213590.1	YmfQ family protein	-
DRA65_RS03755	713118..715091	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
DRA65_RS03760	715882..716193	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
DRA65_RS03765	716201..716479	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DRA65_RS03770	716564..717169	+	606	WP_002219301.1	hypothetical protein	-
DRA65_RS03775	717148..717444	+	297	WP_002221017.1	hypothetical protein	-
DRA65_RS03780	717441..717650	+	210	WP_002222487.1	hypothetical protein	-
DRA65_RS03785	717760..718903	-	1144	Protein_727	ABC transporter ATP-binding protein/permease	-
DRA65_RS03790	719192..719839	-	648	WP_002217218.1	DUF799 domain-containing protein	-
DRA65_RS03795	719836..720204	-	369	WP_002234874.1	DUF4810 domain-containing protein	-
DRA65_RS03800	720214..720885	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	703893..717444	13551
	-	flank	IS/Tn	-	-	710745..711710	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T108086 WP_002242826.1 NZ_CP030826:c716479-716201 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T108086 NZ_CP030826:c716479-716201 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT108086 WP_002221020.1 NZ_CP030826:c716193-715882 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT108086 NZ_CP030826:c716193-715882 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6