Detailed information of TA system TA108083

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 714600..715197
• Replicon: chromosome
• Accession: NZ_CP030822
• Organism: Neisseria meningitidis strain 15-123

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: DRA69_RS03745
• Protein ID: WP_002242826.1
• Coordinates: 714919..715197 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DRA69_RS03740
• Protein ID: WP_002221020.1
• Coordinates: 714600..714911 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRA69_RS03720	710492..710656	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
DRA69_RS03725	710656..711267	+	612	WP_042744707.1	baseplate J/gp47 family protein	-
DRA69_RS03730	711264..711824	+	561	WP_002213590.1	YmfQ family protein	-
DRA69_RS03735	711835..713808	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
DRA69_RS03740	714600..714911	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
DRA69_RS03745	714919..715197	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DRA69_RS03750	715282..715887	+	606	WP_002219301.1	hypothetical protein	-
DRA69_RS03755	715866..716162	+	297	WP_002221017.1	hypothetical protein	-
DRA69_RS03760	716159..716368	+	210	WP_002222487.1	hypothetical protein	-
DRA69_RS03765	716478..717621	-	1144	Protein_723	ABC transporter ATP-binding protein/permease	-
DRA69_RS03770	717910..718557	-	648	WP_002217218.1	DUF799 domain-containing protein	-
DRA69_RS03775	718554..718922	-	369	WP_002234874.1	DUF4810 domain-containing protein	-
DRA69_RS03780	718932..719603	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	702610..716162	13552
	-	flank	IS/Tn	-	-	709462..710427	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T108083 WP_002242826.1 NZ_CP030822:c715197-714919 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T108083 NZ_CP030822:c715197-714919 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT108083 WP_002221020.1 NZ_CP030822:c714911-714600 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT108083 NZ_CP030822:c714911-714600 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6