Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1571700..1572276 Replicon chromosome
Accession NZ_CP030797
Organism Brevibacterium linens strain RS16

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag DSN93_RS06945 Protein ID WP_139907509.1
Coordinates 1571700..1571975 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DSN93_RS06950 Protein ID WP_139907510.1
Coordinates 1571956..1572276 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSN93_RS06920 1567076..1568383 - 1308 WP_139907506.1 nucleotidyltransferase -
DSN93_RS06925 1568380..1569582 - 1203 WP_180987843.1 SAVED domain-containing protein -
DSN93_RS06930 1569756..1570083 + 328 Protein_1365 nucleotidyltransferase -
DSN93_RS06935 1570080..1570413 + 334 Protein_1366 DUF86 domain-containing protein -
DSN93_RS06940 1570674..1571021 - 348 WP_139907508.1 VOC family protein -
DSN93_RS20150 1571186..1571338 + 153 WP_180987844.1 hypothetical protein -
DSN93_RS06945 1571700..1571975 + 276 WP_139907509.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DSN93_RS06950 1571956..1572276 + 321 WP_139907510.1 HigA family addiction module antidote protein Antitoxin
DSN93_RS06955 1572273..1572719 + 447 WP_139907511.1 NUDIX domain-containing protein -
DSN93_RS06960 1572849..1573442 + 594 WP_139907512.1 ArsR family transcriptional regulator -
DSN93_RS06965 1573435..1573875 + 441 WP_139907513.1 HEPN domain-containing protein -
DSN93_RS06970 1573901..1574011 + 111 Protein_1374 DUF933 domain-containing protein -
DSN93_RS06975 1574296..1575330 - 1035 WP_139907514.1 methionine synthase -
DSN93_RS06980 1575348..1576340 - 993 WP_139907515.1 DUF1852 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-85)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-76)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10664.10 Da        Isoelectric Point: 10.0004

>T108077 WP_139907509.1 NZ_CP030797:1571700-1571975 [Brevibacterium linens]
VIRSFGSKDTERIWHEQYVKRVDRTVQRAAMRKLELIHAAKDVEDLRVPPGNRLERLVGDRRGQHSIRVNAQWRICFVWR
EGGADDVELGD

Download         Length: 276 bp

>T108077 NZ_CP030797:1571700-1571975 [Brevibacterium linens]
GTGATCAGATCGTTCGGCAGCAAGGACACCGAGCGCATCTGGCATGAGCAGTACGTCAAGCGCGTCGACCGGACGGTGCA
GCGGGCGGCCATGCGGAAGCTCGAGCTGATCCATGCGGCGAAGGATGTCGAGGACCTCCGGGTCCCGCCGGGCAACCGCC
TGGAGCGTCTGGTCGGCGACCGACGCGGGCAGCACAGCATCCGCGTCAACGCGCAATGGCGTATCTGCTTCGTCTGGAGA
GAGGGAGGTGCGGACGATGTCGAACTCGGCGACTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11871.57 Da        Isoelectric Point: 5.1529

>AT108077 WP_139907510.1 NZ_CP030797:1571956-1572276 [Brevibacterium linens]
MSNSATNTEADLIEPIHPGEILMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTAIRLARYFGTSEELWMNL
QSNYELRLERRVLHDKVAAITPLEVA

Download         Length: 321 bp

>AT108077 NZ_CP030797:1571956-1572276 [Brevibacterium linens]
ATGTCGAACTCGGCGACTAACACTGAGGCCGACCTGATCGAGCCGATCCACCCGGGAGAGATCCTGATGGAGGACTTCAT
CGAGGGCTTCGGGATCACTCAGAACAAGCTCGCGGTGTCCATCGGCGTGCCGCCGCGCCGGATCAACGAGATCGTGCACG
GCAAGCGGGGGATCACCGCTGATACGGCGATCCGTCTGGCGCGCTACTTCGGAACGTCCGAGGAGCTCTGGATGAATCTG
CAGTCGAACTACGAGCTTCGGCTTGAGCGCCGTGTCCTGCACGACAAGGTTGCCGCGATCACACCGTTGGAGGTTGCGTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References