Detailed information of TA system TA108049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2276979..2277541
• Replicon: chromosome
• Accession: NZ_CP030787
• Organism: Escherichia albertii strain 2013C-4143

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CX698_RS11520
• Protein ID: WP_000605681.1
• Coordinates: 2277263..2277541 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CX698_RS11515
• Protein ID: WP_000781369.1
• Coordinates: 2276979..2277263 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CX698_RS11500	2274895..2275779	+	885	WP_113640343.1	formate dehydrogenase N subunit beta	-
CX698_RS11505	2275772..2276425	+	654	WP_000045636.1	formate dehydrogenase-N subunit gamma	-
CX698_RS11510	2276498..2276974	+	477	WP_059225294.1	NUDIX domain-containing protein	-
CX698_RS11515	2276979..2277263	-	285	WP_000781369.1	HigA family addiction module antidote protein	Antitoxin
CX698_RS11520	2277263..2277541	-	279	WP_000605681.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CX698_RS11525	2277727..2278707	-	981	WP_113640344.1	alcohol dehydrogenase AdhP	-
CX698_RS11530	2278842..2280455	-	1614	Protein_2174	malate dehydrogenase	-
CX698_RS11535	2280491..2282053	-	1563	Protein_2175	oxygen-sensing cyclic-di-GMP phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-81)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10562.20 Da
• Isoelectric Point: 8.0733

>T108049 WP_000605681.1 NZ_CP030787:c2277541-2277263 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSVVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRNGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Nucleotide

• Length: 279 bp

>T108049 NZ_CP030787:c2277541-2277263 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGTCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCAATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10371.06 Da
• Isoelectric Point: 8.8567

>AT108049 WP_000781369.1 NZ_CP030787:c2277263-2276979 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Nucleotide

• Length: 285 bp

>AT108049 NZ_CP030787:c2277263-2276979 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAGTAG