Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3882588..3883300 Replicon chromosome
Accession NZ_CP030783
Organism Escherichia albertii strain 2012EL-1823B

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AYN53_RS19760 Protein ID WP_113650514.1
Coordinates 3882588..3882890 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AYN53_RS19765 Protein ID WP_000806446.1
Coordinates 3882962..3883300 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYN53_RS19740 3879251..3880093 + 843 WP_113650511.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
AYN53_RS19745 3880165..3881517 + 1353 WP_113650512.1 glutathione-disulfide reductase -
AYN53_RS19750 3881571..3881654 - 84 WP_001295215.1 hypothetical protein -
AYN53_RS25985 3881682..3881855 + 174 WP_000553433.1 hypothetical protein -
AYN53_RS26140 3881945..3882424 - 480 Protein_3775 hypothetical protein -
AYN53_RS19760 3882588..3882890 + 303 WP_113650514.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYN53_RS19765 3882962..3883300 + 339 WP_000806446.1 HigA family addiction module antidote protein Antitoxin
AYN53_RS25995 3883357..3883515 + 159 WP_164508675.1 hypothetical protein -
AYN53_RS19770 3883864..3884430 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
AYN53_RS19775 3884577..3885107 + 531 WP_000480294.1 LuxR family transcriptional regulator -
AYN53_RS19780 3885179..3886207 - 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
AYN53_RS19785 3886256..3888238 - 1983 WP_125295787.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11870.60 Da        Isoelectric Point: 10.0443

>T108034 WP_113650514.1 NZ_CP030783:3882588-3882890 [Escherichia albertii]
MTKKINIKNFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

>T108034 NZ_CP030783:3882588-3882890 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGAATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAAGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT108034 WP_000806446.1 NZ_CP030783:3882962-3883300 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp

>AT108034 NZ_CP030783:3882962-3883300 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References