Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 146048..146306 Replicon chromosome
Accession NZ_CP030783
Organism Escherichia albertii strain 2012EL-1823B

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AYN53_RS00765 Protein ID WP_000809168.1
Coordinates 146048..146200 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 146249..146306 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYN53_RS00750 141459..143375 + 1917 WP_000516135.1 molecular chaperone DnaK -
AYN53_RS00755 143464..144594 + 1131 WP_001118445.1 molecular chaperone DnaJ -
AYN53_RS00760 144857..145970 - 1114 Protein_142 IS4 family transposase -
AYN53_RS00765 146048..146200 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 146249..146306 + 58 - - Antitoxin
AYN53_RS00770 146822..147583 + 762 Protein_144 hypothetical protein -
AYN53_RS00775 147604..149097 + 1494 WP_113649461.1 sulfatase-like hydrolase/transferase -
AYN53_RS00780 149251..150498 + 1248 WP_059267798.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - espX1 144857..154436 9579


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T108014 WP_000809168.1 NZ_CP030783:c146200-146048 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T108014 NZ_CP030783:c146200-146048 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT108014 NZ_CP030783:146249-146306 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References