Detailed information of TA system TA107998

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-agrB/SymE(toxin)
• Location: 4613377..4613789
• Replicon: chromosome
• Accession: NZ_CP030781
• Organism: Escherichia albertii strain 07-3866

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8H9KBI8
• Locus tag: CCF18_RS22880
• Protein ID: WP_059273478.1
• Coordinates: 4613377..4613718 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4613713..4613789 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF18_RS22860	4608409..4609341	+	933	WP_059255468.1	Rpn family recombination-promoting nuclease/putative transposase	-
CCF18_RS22865	4609656..4610734	+	1079	Protein_4357	hypothetical protein	-
CCF18_RS22870	4610790..4611836	-	1047	WP_072249344.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
CCF18_RS22875	4611836..4613215	-	1380	WP_059273479.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
CCF18_RS22880	4613377..4613718	-	342	WP_059273478.1	endoribonuclease SymE	Toxin
-	4613713..4613789	+	77	NuclAT_10	-	Antitoxin
-	4613713..4613789	+	77	NuclAT_10	-	Antitoxin
-	4613713..4613789	+	77	NuclAT_10	-	Antitoxin
-	4613713..4613789	+	77	NuclAT_10	-	Antitoxin
-	4613713..4613789	+	77	NuclAT_11	-	Antitoxin
-	4613713..4613789	+	77	NuclAT_11	-	Antitoxin
-	4613713..4613789	+	77	NuclAT_11	-	Antitoxin
-	4613713..4613789	+	77	NuclAT_11	-	Antitoxin
CCF18_RS22885	4613946..4615427	-	1482	WP_105210846.1	restriction endonuclease subunit S	-
CCF18_RS22890	4615424..4617013	-	1590	WP_125317821.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12350.15 Da
• Isoelectric Point: 7.8538

>T107998 WP_059273478.1 NZ_CP030781:c4613718-4613377 [Escherichia albertii]
MTDTHSIAQQFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIDVKVMEGCIVLTAHPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T107998 NZ_CP030781:c4613718-4613377 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACAGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGATAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCACCCCCCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT107998 NZ_CP030781:4613713-4613789 [Escherichia albertii]
AGTCATGATTACTATTCCTTAGAAATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin