Detailed information of TA system TA107997

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4042038..4042640
• Replicon: chromosome
• Accession: NZ_CP030781
• Organism: Escherichia albertii strain 07-3866

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8H9KB27
• Locus tag: CCF18_RS20115
• Protein ID: WP_000897299.1
• Coordinates: 4042038..4042349 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CCF18_RS20120
• Protein ID: WP_000356397.1
• Coordinates: 4042350..4042640 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF18_RS20085	4037066..4037851	+	786	WP_000059671.1	DeoR/GlpR family DNA-binding transcription regulator	-
CCF18_RS20090	4037950..4038549	+	600	WP_002460585.1	glucose-1-phosphatase	-
CCF18_RS20095	4038543..4039415	+	873	WP_000916663.1	virulence factor BrkB family protein	-
CCF18_RS20100	4039412..4039849	+	438	WP_000560977.1	D-tyrosyl-tRNA(Tyr) deacylase	-
CCF18_RS20105	4039894..4040835	+	942	WP_001297068.1	fatty acid biosynthesis protein FabY	-
CCF18_RS20110	4040901..4041809	-	909	WP_010342110.1	alpha/beta hydrolase	-
CCF18_RS20115	4042038..4042349	+	312	WP_000897299.1	hypothetical protein	Toxin
CCF18_RS20120	4042350..4042640	+	291	WP_000356397.1	helix-turn-helix domain-containing protein	Antitoxin
CCF18_RS20130	4042999..4043277	+	279	WP_032278934.1	hypothetical protein	-
CCF18_RS20135	4043692..4043910	+	219	WP_001251292.1	ribbon-helix-helix domain-containing protein	-
CCF18_RS20140	4044128..4044370	+	243	Protein_3844	CopG family transcriptional regulator	-
CCF18_RS20145	4044370..4044729	+	360	Protein_3845	type II toxin-antitoxin system VapC family toxin	-
CCF18_RS20150	4044766..4045695	-	930	WP_000027704.1	formate dehydrogenase accessory protein FdhE	-
CCF18_RS20155	4045692..4046327	-	636	WP_000829019.1	formate dehydrogenase cytochrome b556 subunit	-
CCF18_RS20160	4046324..4047226	-	903	WP_000331386.1	formate dehydrogenase O subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12251.24 Da
• Isoelectric Point: 9.7791

>T107997 WP_000897299.1 NZ_CP030781:4042038-4042349 [Escherichia albertii]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWFSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Nucleotide

• Length: 312 bp

>T107997 NZ_CP030781:4042038-4042349 [Escherichia albertii]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGTTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10846.43 Da
• Isoelectric Point: 10.8907

>AT107997 WP_000356397.1 NZ_CP030781:4042350-4042640 [Escherichia albertii]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Nucleotide

• Length: 291 bp

>AT107997 NZ_CP030781:4042350-4042640 [Escherichia albertii]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG