Detailed information of TA system TA107995

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3677351..3677608
• Replicon: chromosome
• Accession: NZ_CP030781
• Organism: Escherichia albertii strain 07-3866

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: CCF18_RS18400
• Protein ID: WP_001135738.1
• Coordinates: 3677351..3677503 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3677554..3677608 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF18_RS18375	3673455..3674114	+	660	WP_029397571.1	OmpA family lipoprotein	-
CCF18_RS18380	3674218..3675192	+	975	WP_125317713.1	glyoxylate/hydroxypyruvate reductase GhrB	-
CCF18_RS18385	3675245..3675955	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
CCF18_RS18390	3676378..3676668	+	291	WP_000455794.1	HTH-type transcriptional regulator	-
CCF18_RS18395	3676951..3677163	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
CCF18_RS18400	3677351..3677503	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	3677554..3677608	+	55	-	-	Antitoxin
CCF18_RS18405	3677825..3679894	-	2070	WP_001291807.1	glycine--tRNA ligase subunit beta	-
CCF18_RS18410	3679904..3680815	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
CCF18_RS18415	3680911..3681210	-	300	WP_000979961.1	YsaB family lipoprotein	-
CCF18_RS18420	3681383..3682378	+	996	WP_001182625.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T107995 WP_001135738.1 NZ_CP030781:c3677503-3677351 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T107995 NZ_CP030781:c3677503-3677351 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT107995 NZ_CP030781:3677554-3677608 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin