Detailed information of TA system TA107993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 3248359..3249158
• Replicon: chromosome
• Accession: NZ_CP030781
• Organism: Escherichia albertii strain 07-3866

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: A0A8H9C2I0
• Locus tag: CCF18_RS16180
• Protein ID: WP_059227548.1
• Coordinates: 3248694..3249158 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: S1PPV5
• Locus tag: CCF18_RS16175
• Protein ID: WP_001296435.1
• Coordinates: 3248359..3248694 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF18_RS16160	3244149..3244919	-	771	WP_125317665.1	2-dehydro-3-deoxyglucarate aldolase	-
CCF18_RS16165	3244935..3246269	-	1335	WP_025238277.1	galactarate/glucarate/glycerate transporter GarP	-
CCF18_RS16170	3246639..3248210	+	1572	WP_059256163.1	galactarate dehydratase	-
CCF18_RS16175	3248359..3248694	+	336	WP_001296435.1	type II toxin-antitoxin system antitoxin PrlF	Antitoxin
CCF18_RS16180	3248694..3249158	+	465	WP_059227548.1	type II toxin-antitoxin system ribonuclease toxin YhaV	Toxin
CCF18_RS16185	3249213..3250022	-	810	WP_000072169.1	aga operon transcriptional regulator AgaR	-
CCF18_RS16190	3250271..3251551	+	1281	WP_125317666.1	tagatose-bisphosphate aldolase subunit KbaZ	-
CCF18_RS16195	3251574..3252047	+	474	WP_002461030.1	PTS N-acetylgalactosamine transporter subunit IIB	-
CCF18_RS16200	3252058..3252837	+	780	WP_000406226.1	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	-
CCF18_RS16205	3252827..3253705	+	879	WP_001295548.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
CCF18_RS16210	3253723..3254157	+	435	WP_000948824.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (14-110)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17819.26 Da
• Isoelectric Point: 9.7301

>T107993 WP_059227548.1 NZ_CP030781:3248694-3249158 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Nucleotide

• Length: 465 bp

>T107993 NZ_CP030781:3248694-3249158 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTTTCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACAGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12321.92 Da
• Isoelectric Point: 4.5392

>AT107993 WP_001296435.1 NZ_CP030781:3248359-3248694 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Nucleotide

• Length: 336 bp

>AT107993 NZ_CP030781:3248359-3248694 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: S1PPV5