Detailed information of TA system TA107982

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1605548..1605773
• Replicon: chromosome
• Accession: NZ_CP030781
• Organism: Escherichia albertii strain 07-3866

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A7L6L988
• Locus tag: CCF18_RS07975
• Protein ID: WP_000813269.1
• Coordinates: 1605548..1605703 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1605715..1605773 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF18_RS07930	1600829..1601326	-	498	WP_084818379.1	lysozyme RrrD	-
CCF18_RS07935	1601326..1601541	-	216	WP_125317407.1	class II holin family protein	-
CCF18_RS07950	1602342..1603160	-	819	WP_072250181.1	CPBP family intramembrane metalloprotease	-
CCF18_RS07955	1603303..1603671	-	369	WP_059217965.1	antitermination protein	-
CCF18_RS07960	1603664..1604041	-	378	WP_125317408.1	RusA family crossover junction endodeoxyribonuclease	-
CCF18_RS07965	1604042..1605100	-	1059	WP_125317409.1	DUF968 domain-containing protein	-
CCF18_RS07970	1605102..1605380	-	279	WP_059225803.1	hypothetical protein	-
CCF18_RS07975	1605548..1605703	-	156	WP_000813269.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1605715..1605773	+	59	-	-	Antitoxin
CCF18_RS07990	1606309..1607082	+	774	WP_059274496.1	alpha/beta hydrolase	-
CCF18_RS07995	1607438..1607848	-	411	WP_059274497.1	DUF977 family protein	-
CCF18_RS08000	1607856..1608617	-	762	WP_059274498.1	DUF1627 domain-containing protein	-
CCF18_RS08005	1608641..1609387	-	747	WP_059274499.1	ATP-binding protein	-
CCF18_RS08010	1609394..1610356	-	963	WP_125317411.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1579575..1618070	38495

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T107982 WP_000813269.1 NZ_CP030781:c1605703-1605548 [Escherichia albertii]
MKQQKAMLVALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T107982 NZ_CP030781:c1605703-1605548 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT107982 NZ_CP030781:1605715-1605773 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A7L6L988

Antitoxin