Detailed information of TA system TA107969

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 39228..39482
• Replicon: plasmid unnamed1
• Accession: NZ_CP030779
• Organism: Escherichia albertii strain 05-3106

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: CYM74_RS23475
• Protein ID: WP_000876345.1
• Coordinates: 39228..39434 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	39426..39482 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYM74_RS23430	34603..35085	-	483	WP_001311056.1	hypothetical protein	-
CYM74_RS23435	35202..36013	-	812	Protein_39	3'-5' exoribonuclease	-
CYM74_RS23440	36059..36340	-	282	WP_044718080.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CYM74_RS23445	36337..36606	-	270	WP_000079928.1	hypothetical protein	-
CYM74_RS23455	37522..38379	-	858	WP_000130987.1	incFII family plasmid replication initiator RepA	-
CYM74_RS23460	38372..38446	-	75	WP_001365705.1	RepA leader peptide Tap	-
CYM74_RS23470	38684..38944	-	261	WP_000078108.1	replication regulatory protein RepA	-
CYM74_RS23475	39228..39434	-	207	WP_000876345.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	39426..39482	+	57	NuclAT_0	-	Antitoxin
-	39426..39482	+	57	NuclAT_0	-	Antitoxin
-	39426..39482	+	57	NuclAT_0	-	Antitoxin
-	39426..39482	+	57	NuclAT_0	-	Antitoxin
CYM74_RS23480	39723..39932	-	210	WP_024234785.1	hemolysin expression modulator Hha	-
CYM74_RS23485	39988..40224	-	237	WP_000376558.1	hypothetical protein	-
CYM74_RS23490	40311..41324	-	1014	WP_000118342.1	hypothetical protein	-
CYM74_RS23495	41431..41697	-	267	WP_113623322.1	hypothetical protein	-
CYM74_RS23500	41736..42518	-	783	WP_001317493.1	IS21-like element IS100kyp family helper ATPase IstB	-
CYM74_RS23505	42515..43537	-	1023	WP_000255946.1	IS21-like element IS100 family transposase	-
CYM74_RS23510	43604..43777	-	174	WP_206430860.1	hypothetical protein	-
CYM74_RS23520	44171..44419	+	249	WP_000618110.1	DinI-like family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	bfpF / bfpE / bfpD / bfpA	1..56603	56603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (23-64)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7806.32 Da
• Isoelectric Point: 8.8807

>T107969 WP_000876345.1 NZ_CP030779:c39434-39228 [Escherichia albertii]
MKYLNTTDCSLFLAERSKFMTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQITLAYEARK

Nucleotide

• Length: 207 bp

>T107969 NZ_CP030779:c39434-39228 [Escherichia albertii]
ATGAAGTACTTGAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTGTGTGAGCTGAATATTCACAGGG
GAAATACAGTGGTGCAGATAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT107969 NZ_CP030779:39426-39482 [Escherichia albertii]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin