Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3946576..3946822 Replicon chromosome
Accession NZ_CP030778
Organism Escherichia albertii strain 05-3106

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag CYM74_RS19350 Protein ID WP_000956458.1
Coordinates 3946670..3946822 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3946576..3946628 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYM74_RS19330 3941980..3943779 + 1800 WP_113623171.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
CYM74_RS19335 3943779..3945491 + 1713 WP_044708375.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
CYM74_RS19340 3945671..3946405 + 735 WP_059214466.1 phosphoadenosine phosphosulfate reductase -
- 3946576..3946628 - 53 - - Antitoxin
CYM74_RS19350 3946670..3946822 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
CYM74_RS19355 3947015..3948127 - 1113 WP_024179954.1 IS4-like element IS421 family transposase -
CYM74_RS19360 3948297..3949334 - 1038 WP_059253936.1 aminopeptidase -
CYM74_RS19365 3949587..3950495 + 909 WP_000372392.1 sulfate adenylyltransferase subunit CysD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T107964 WP_000956458.1 NZ_CP030778:3946670-3946822 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T107964 NZ_CP030778:3946670-3946822 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 53 bp

>AT107964 NZ_CP030778:c3946628-3946576 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References