Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3137824..3138455 Replicon chromosome
Accession NZ_CP030778
Organism Escherichia albertii strain 05-3106

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CYM74_RS15365 Protein ID WP_072243837.1
Coordinates 3138234..3138455 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CYM74_RS15360 Protein ID WP_000806446.1
Coordinates 3137824..3138162 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYM74_RS15335 3132878..3134860 + 1983 WP_113623064.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
CYM74_RS15340 3134909..3135937 + 1029 WP_103054025.1 hematinate-forming heme oxygenase ChuS -
CYM74_RS15345 3136009..3136539 - 531 WP_113623065.1 LuxR family transcriptional regulator -
CYM74_RS15350 3136686..3137252 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
CYM74_RS15355 3137588..3137767 - 180 WP_002460167.1 hypothetical protein -
CYM74_RS15360 3137824..3138162 - 339 WP_000806446.1 HigA family addiction module antidote protein Antitoxin
CYM74_RS15365 3138234..3138455 - 222 WP_072243837.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CYM74_RS15370 3138699..3139178 + 480 WP_000532312.1 hypothetical protein -
CYM74_RS24220 3139268..3139441 - 174 WP_044708027.1 hypothetical protein -
CYM74_RS15375 3139469..3139552 + 84 WP_077871133.1 Damage inducible protein -
CYM74_RS15380 3139606..3140958 - 1353 WP_044708025.1 glutathione-disulfide reductase -
CYM74_RS15385 3141030..3141872 - 843 WP_044708024.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-71)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8518.68 Da        Isoelectric Point: 9.7394

>T107962 WP_072243837.1 NZ_CP030778:c3138455-3138234 [Escherichia albertii]
IPSDIHITLLRKLDITNAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYRLIFKWVNGKAEDLYLDPHKY

Download         Length: 222 bp

>T107962 NZ_CP030778:c3138455-3138234 [Escherichia albertii]
ATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTACCAATGCCGCAACGACCTGGAAGGACTTGAGATC
ACCACCAGGTAATCGGTATGAAGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGGT
TAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT107962 WP_000806446.1 NZ_CP030778:c3138162-3137824 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp

>AT107962 NZ_CP030778:c3138162-3137824 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References