Detailed information of TA system TA107960

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3056614..3056871
• Replicon: chromosome
• Accession: NZ_CP030778
• Organism: Escherichia albertii strain 05-3106

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: CYM74_RS15010
• Protein ID: WP_001135738.1
• Coordinates: 3056719..3056871 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3056614..3056668 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYM74_RS14990	3051844..3052839	-	996	WP_001182625.1	acyltransferase	-
CYM74_RS14995	3053012..3053311	+	300	WP_000979961.1	YsaB family lipoprotein	-
CYM74_RS15000	3053407..3054318	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
CYM74_RS15005	3054328..3056397	+	2070	WP_001291807.1	glycine--tRNA ligase subunit beta	-
-	3056614..3056668	-	55	-	-	Antitoxin
CYM74_RS15010	3056719..3056871	+	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
CYM74_RS15015	3057059..3057271	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
CYM74_RS15020	3057554..3057844	-	291	WP_000455794.1	HTH-type transcriptional regulator	-
CYM74_RS15025	3058267..3058977	+	711	WP_059254282.1	DUF3053 domain-containing protein	-
CYM74_RS15030	3059030..3060004	-	975	WP_000804993.1	glyoxylate/hydroxypyruvate reductase GhrB	-
CYM74_RS15035	3060108..3060767	-	660	WP_000747625.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T107960 WP_001135738.1 NZ_CP030778:3056719-3056871 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T107960 NZ_CP030778:3056719-3056871 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT107960 NZ_CP030778:c3056668-3056614 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin