Detailed information of TA system TA107951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1855712..1856362
• Replicon: chromosome
• Accession: NZ_CP030778
• Organism: Escherichia albertii strain 05-3106

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CYM74_RS09330
• Protein ID: WP_000263532.1
• Coordinates: 1856021..1856362 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A3T5VD61
• Locus tag: CYM74_RS09325
• Protein ID: WP_025237546.1
• Coordinates: 1855712..1856011 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYM74_RS09295	1851148..1851459	-	312	WP_044710441.1	hypothetical protein	-
CYM74_RS09300	1851464..1851856	-	393	WP_000273381.1	flagellar export chaperone FliS	-
CYM74_RS09305	1851879..1853195	-	1317	WP_113622924.1	flagellar filament capping protein FliD	-
CYM74_RS09315	1853402..1854316	-	915	WP_000949079.1	lateral flagellin LafA	-
CYM74_RS09320	1854803..1855654	+	852	WP_125295984.1	winged helix-turn-helix domain-containing protein	-
CYM74_RS09325	1855712..1856011	-	300	WP_025237546.1	XRE family transcriptional regulator	Antitoxin
CYM74_RS09330	1856021..1856362	-	342	WP_000263532.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CYM74_RS09335	1856438..1857415	-	978	WP_113622926.1	flagellar hook-associated protein	-
CYM74_RS09340	1857432..1858361	-	930	WP_113622927.1	flagellar hook-associated protein FlgL	-
CYM74_RS09345	1858376..1859752	-	1377	WP_113622928.1	flagellar hook-associated protein FlgK	-
CYM74_RS09350	1859845..1860144	-	300	WP_059254376.1	rod-binding protein	-
CYM74_RS09355	1860144..1861244	-	1101	WP_125295985.1	flagellar basal body P-ring protein FlgI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (8-88)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13031.86 Da
• Isoelectric Point: 6.4677

>T107951 WP_000263532.1 NZ_CP030778:c1856362-1856021 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRKHLKK

Nucleotide

• Length: 342 bp

>T107951 NZ_CP030778:c1856362-1856021 [Escherichia albertii]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTGCTTGC
TGCAATGCTGATTCTTGCAGAGTATGGCCCACAGTTGGGCAGGCCCTTTGCGGACACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCAGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10962.78 Da
• Isoelectric Point: 9.7665

>AT107951 WP_025237546.1 NZ_CP030778:c1856011-1855712 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Nucleotide

• Length: 300 bp

>AT107951 NZ_CP030778:c1856011-1855712 [Escherichia albertii]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACCCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCTAATGGTAAGAGAGTTGCATTTCAGATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A3T5VD61