Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 588550..589112 Replicon chromosome
Accession NZ_CP030778
Organism Escherichia albertii strain 05-3106

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag CYM74_RS03025 Protein ID WP_000605679.1
Coordinates 588550..588828 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag CYM74_RS03030 Protein ID WP_000781370.1
Coordinates 588828..589112 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYM74_RS03005 584553..584984 - 432 WP_000152289.1 peroxiredoxin OsmC -
CYM74_RS03010 585228..585365 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
CYM74_RS03015 585522..587219 + 1698 WP_000433442.1 malate dehydrogenase -
CYM74_RS03020 587354..588364 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
CYM74_RS03025 588550..588828 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CYM74_RS03030 588828..589112 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
CYM74_RS03035 589340..589993 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
CYM74_RS03040 589986..590870 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
CYM74_RS03045 590883..593930 - 3048 WP_098402488.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T107948 WP_000605679.1 NZ_CP030778:588550-588828 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T107948 NZ_CP030778:588550-588828 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT107948 WP_000781370.1 NZ_CP030778:588828-589112 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT107948 NZ_CP030778:588828-589112 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References