Detailed information of TA system TA107945

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 294895..295120
• Replicon: chromosome
• Accession: NZ_CP030778
• Organism: Escherichia albertii strain 05-3106

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: CYM74_RS01550
• Protein ID: WP_000813254.1
• Coordinates: 294965..295120 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	294895..294953 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYM74_RS01520	290206..291276	+	1071	WP_001262357.1	hypothetical protein	-
CYM74_RS01525	291317..291739	+	423	WP_001151199.1	DUF977 family protein	-
CYM74_RS01530	292002..293390	-	1389	Protein_298	hypothetical protein	-
CYM74_RS01535	293480..294388	-	909	WP_001297700.1	bacteriophage abortive infection AbiH family protein	-
-	294895..294953	-	59	-	-	Antitoxin
CYM74_RS01550	294965..295120	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
CYM74_RS01555	295579..295857	+	279	WP_001325325.1	hypothetical protein	-
CYM74_RS01560	295859..296908	+	1050	WP_001265274.1	DUF968 domain-containing protein	-
CYM74_RS01565	296926..297303	+	378	WP_001204787.1	antitermination protein	-
CYM74_RS01570	297459..297983	-	525	WP_000780584.1	lipocalin family protein	-
CYM74_RS01575	298176..299135	+	960	WP_000592549.1	DUF523 and DUF1722 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	278950..327866	48916

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T107945 WP_000813254.1 NZ_CP030778:294965-295120 [Escherichia albertii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T107945 NZ_CP030778:294965-295120 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT107945 NZ_CP030778:c294953-294895 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin