Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2662666..2662924 Replicon chromosome
Accession NZ_CP030768
Organism Escherichia coli strain 2017C-4173W12

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag DSB71_RS13610 Protein ID WP_000809168.1
Coordinates 2662666..2662818 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2662867..2662924 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSB71_RS13590 2657908..2658621 - 714 WP_001102367.1 acidic protein MsyB -
DSB71_RS13595 2658647..2659051 - 405 WP_000843584.1 DUF2541 family protein -
DSB71_RS13600 2659427..2661343 + 1917 WP_000516135.1 molecular chaperone DnaK -
DSB71_RS13605 2661432..2662562 + 1131 WP_001118464.1 molecular chaperone DnaJ -
DSB71_RS13610 2662666..2662818 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 2662867..2662924 + 58 - - Antitoxin
DSB71_RS13615 2663404..2664570 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
DSB71_RS13620 2664636..2665535 + 900 WP_001300855.1 transcriptional activator NhaR -
DSB71_RS13625 2665573..2666532 - 960 WP_000871674.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T107905 WP_000809168.1 NZ_CP030768:c2662818-2662666 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T107905 NZ_CP030768:c2662818-2662666 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT107905 NZ_CP030768:2662867-2662924 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References