Detailed information of TA system TA107881

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4019793..4020014
• Replicon: chromosome
• Accession: NZ_CP030767
• Organism: Escherichia coli strain 2017C-4109

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: DSB73_RS22015
• Protein ID: WP_001295224.1
• Coordinates: 4019793..4019900 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4019949..4020014 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSB73_RS21990	4015045..4015797	-	753	Protein_3932	cellulose biosynthesis protein BcsQ	-
DSB73_RS21995	4015809..4015997	-	189	WP_001063316.1	YhjR family protein	-
DSB73_RS22000	4016270..4017841	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
DSB73_RS22005	4017838..4018029	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
DSB73_RS22010	4018026..4019706	+	1681	Protein_3936	cellulose biosynthesis protein BcsG	-
DSB73_RS22015	4019793..4019900	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4019949..4020014	+	66	NuclAT_16	-	Antitoxin
-	4019949..4020014	+	66	NuclAT_16	-	Antitoxin
-	4019949..4020014	+	66	NuclAT_16	-	Antitoxin
-	4019949..4020014	+	66	NuclAT_16	-	Antitoxin
-	4019949..4020014	+	66	NuclAT_21	-	Antitoxin
-	4019949..4020014	+	66	NuclAT_21	-	Antitoxin
-	4019949..4020014	+	66	NuclAT_21	-	Antitoxin
-	4019949..4020014	+	66	NuclAT_21	-	Antitoxin
DSB73_RS22025	4020376..4021647	+	1272	WP_001301684.1	amino acid permease	-
DSB73_RS22030	4021677..4022681	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
DSB73_RS22035	4022678..4023661	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
DSB73_RS22040	4023672..4024574	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T107881 WP_001295224.1 NZ_CP030767:c4019900-4019793 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T107881 NZ_CP030767:c4019900-4019793 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT107881 NZ_CP030767:4019949-4020014 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin