Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1278404..1278618 Replicon chromosome
Accession NZ_CP030767
Organism Escherichia coli strain 2017C-4109

Toxin (Protein)


Gene name ldrD Uniprot ID J7R083
Locus tag DSB73_RS07480 Protein ID WP_000170963.1
Coordinates 1278404..1278511 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1278559..1278618 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSB73_RS07450 1273713..1274795 + 1083 WP_000804726.1 peptide chain release factor 1 -
DSB73_RS07455 1274795..1275628 + 834 WP_000456466.1 peptide chain release factor N(5)-glutamine methyltransferase -
DSB73_RS07460 1275625..1276017 + 393 WP_000200379.1 invasion regulator SirB2 -
DSB73_RS07465 1276021..1276830 + 810 WP_001257044.1 invasion regulator SirB1 -
DSB73_RS07470 1276866..1277720 + 855 WP_000811067.1 3-deoxy-8-phosphooctulonate synthase -
DSB73_RS07475 1277868..1277975 - 108 WP_000170954.1 type I toxin-antitoxin system toxin Ldr family protein -
- 1278028..1278089 + 62 NuclAT_24 - -
- 1278028..1278089 + 62 NuclAT_24 - -
- 1278028..1278089 + 62 NuclAT_24 - -
- 1278028..1278089 + 62 NuclAT_24 - -
- 1278028..1278089 + 62 NuclAT_26 - -
- 1278028..1278089 + 62 NuclAT_26 - -
- 1278028..1278089 + 62 NuclAT_26 - -
- 1278028..1278089 + 62 NuclAT_26 - -
- 1278028..1278089 + 62 NuclAT_28 - -
- 1278028..1278089 + 62 NuclAT_28 - -
- 1278028..1278089 + 62 NuclAT_28 - -
- 1278028..1278089 + 62 NuclAT_28 - -
- 1278028..1278089 + 62 NuclAT_30 - -
- 1278028..1278089 + 62 NuclAT_30 - -
- 1278028..1278089 + 62 NuclAT_30 - -
- 1278028..1278089 + 62 NuclAT_30 - -
- 1278028..1278089 + 62 NuclAT_32 - -
- 1278028..1278089 + 62 NuclAT_32 - -
- 1278028..1278089 + 62 NuclAT_32 - -
- 1278028..1278089 + 62 NuclAT_32 - -
- 1278028..1278090 + 63 NuclAT_17 - -
- 1278028..1278090 + 63 NuclAT_17 - -
- 1278028..1278090 + 63 NuclAT_17 - -
- 1278028..1278090 + 63 NuclAT_17 - -
- 1278028..1278090 + 63 NuclAT_18 - -
- 1278028..1278090 + 63 NuclAT_18 - -
- 1278028..1278090 + 63 NuclAT_18 - -
- 1278028..1278090 + 63 NuclAT_18 - -
- 1278028..1278090 + 63 NuclAT_19 - -
- 1278028..1278090 + 63 NuclAT_19 - -
- 1278028..1278090 + 63 NuclAT_19 - -
- 1278028..1278090 + 63 NuclAT_19 - -
- 1278028..1278090 + 63 NuclAT_20 - -
- 1278028..1278090 + 63 NuclAT_20 - -
- 1278028..1278090 + 63 NuclAT_20 - -
- 1278028..1278090 + 63 NuclAT_20 - -
- 1278028..1278090 + 63 NuclAT_22 - -
- 1278028..1278090 + 63 NuclAT_22 - -
- 1278028..1278090 + 63 NuclAT_22 - -
- 1278028..1278090 + 63 NuclAT_22 - -
- 1278028..1278090 + 63 NuclAT_23 - -
- 1278028..1278090 + 63 NuclAT_23 - -
- 1278028..1278090 + 63 NuclAT_23 - -
- 1278028..1278090 + 63 NuclAT_23 - -
DSB73_RS07480 1278404..1278511 - 108 WP_000170963.1 small toxic polypeptide LdrB Toxin
- 1278559..1278618 + 60 NuclAT_25 - Antitoxin
- 1278559..1278618 + 60 NuclAT_25 - Antitoxin
- 1278559..1278618 + 60 NuclAT_25 - Antitoxin
- 1278559..1278618 + 60 NuclAT_25 - Antitoxin
- 1278559..1278618 + 60 NuclAT_27 - Antitoxin
- 1278559..1278618 + 60 NuclAT_27 - Antitoxin
- 1278559..1278618 + 60 NuclAT_27 - Antitoxin
- 1278559..1278618 + 60 NuclAT_27 - Antitoxin
- 1278559..1278618 + 60 NuclAT_29 - Antitoxin
- 1278559..1278618 + 60 NuclAT_29 - Antitoxin
- 1278559..1278618 + 60 NuclAT_29 - Antitoxin
- 1278559..1278618 + 60 NuclAT_29 - Antitoxin
- 1278559..1278618 + 60 NuclAT_31 - Antitoxin
- 1278559..1278618 + 60 NuclAT_31 - Antitoxin
- 1278559..1278618 + 60 NuclAT_31 - Antitoxin
- 1278559..1278618 + 60 NuclAT_31 - Antitoxin
- 1278559..1278618 + 60 NuclAT_33 - Antitoxin
- 1278559..1278618 + 60 NuclAT_33 - Antitoxin
- 1278559..1278618 + 60 NuclAT_33 - Antitoxin
- 1278559..1278618 + 60 NuclAT_33 - Antitoxin
DSB73_RS07485 1278910..1280010 - 1101 WP_001301956.1 sodium-potassium/proton antiporter ChaA -
DSB73_RS07490 1280280..1280510 + 231 WP_001146444.1 putative cation transport regulator ChaB -
DSB73_RS07495 1280671..1281366 + 696 WP_001301489.1 glutathione-specific gamma-glutamylcyclotransferase -
DSB73_RS07500 1281410..1281763 - 354 WP_120795322.1 DsrE/F sulfur relay family protein YchN -
DSB73_RS07505 1281949..1283343 + 1395 WP_000086192.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3971.74 Da        Isoelectric Point: 11.4779

>T107861 WP_000170963.1 NZ_CP030767:c1278511-1278404 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T107861 NZ_CP030767:c1278511-1278404 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 60 bp

>AT107861 NZ_CP030767:1278559-1278618 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References