Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 11977..12562 Replicon plasmid unnamed3
Accession NZ_CP030757
Organism Acinetobacter schindleri strain H3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DPR03_RS15765 Protein ID WP_145758468.1
Coordinates 12242..12562 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DPR03_RS15760 Protein ID WP_004896911.1
Coordinates 11977..12249 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPR03_RS15730 7276..7965 + 690 WP_145758469.1 hypothetical protein -
DPR03_RS15735 9110..10033 + 924 WP_145758470.1 replication initiation protein RepM -
DPR03_RS15740 10112..10636 + 525 WP_145758466.1 plasmid replication DNA-binding protein -
DPR03_RS15745 10953..11288 + 336 WP_071321338.1 hypothetical protein -
DPR03_RS15750 11302..11526 + 225 WP_071321337.1 DUF2798 domain-containing protein -
DPR03_RS15760 11977..12249 - 273 WP_004896911.1 helix-turn-helix domain-containing protein Antitoxin
DPR03_RS15765 12242..12562 - 321 WP_145758468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DPR03_RS15770 12702..13379 - 678 WP_143045205.1 RloB domain-containing protein -
DPR03_RS15775 13394..14683 - 1290 WP_071321328.1 ATP-binding protein -
DPR03_RS15780 14911..15240 - 330 WP_071321327.1 hypothetical protein -
DPR03_RS15785 15467..16816 - 1350 WP_071321326.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..29258 29258


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12255.10 Da        Isoelectric Point: 7.9835

>T107845 WP_145758468.1 NZ_CP030757:c12562-12242 [Acinetobacter schindleri]
MLFIETSIFTKQIKELLSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSMKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T107845 NZ_CP030757:c12562-12242 [Acinetobacter schindleri]
ATGTTATTCATTGAAACCAGTATTTTTACCAAGCAAATCAAAGAGCTTTTGAGTGATGAAGAGTATCGTCAGCTTCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGCGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGTAAAAGTGGCGGTATCCGTGTGATCTATTACTGGGTCACAGAAGATGATCAGATATTTTTCCTGGTGGCTTAT
CCAAAGTCTATGAAAGATAATCTGACAGACAAAGAGACCTCTATTTTGCGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10126.59 Da        Isoelectric Point: 7.2045

>AT107845 WP_004896911.1 NZ_CP030757:c12249-11977 [Acinetobacter schindleri]
MDNNLFDDLVASIKEAGAIKRNEMKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT107845 NZ_CP030757:c12249-11977 [Acinetobacter schindleri]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAACGCAATGAAATGAAAGCAAG
CCGGGTAACTGAGCTTGAATTGCCGGATATTAAGGAAGTACGTGAGAAGACAGGCTTAACCCAAGCTGAATTTGCTGCAC
GTTTGCATATCAGTGCCAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACGCTAATT
CGTATTCTGGATGCCCATCCAACTCTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References