Detailed information of TA system TA107844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2224..2809
• Replicon: plasmid unnamed3
• Accession: NZ_CP030757
• Organism: Acinetobacter schindleri strain H3

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DPR03_RS15705
• Protein ID: WP_145758468.1
• Coordinates: 2489..2809 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DPR03_RS15700
• Protein ID: WP_004896911.1
• Coordinates: 2224..2496 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPR03_RS15680	365..889	+	525	WP_145758466.1	plasmid replication DNA-binding protein	-
DPR03_RS15685	1205..1486	+	282	WP_145758467.1	hypothetical protein	-
DPR03_RS15690	1551..1774	+	224	Protein_3	DUF2798 domain-containing protein	-
DPR03_RS15700	2224..2496	-	273	WP_004896911.1	helix-turn-helix domain-containing protein	Antitoxin
DPR03_RS15705	2489..2809	-	321	WP_145758468.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DPR03_RS15710	2949..3626	-	678	WP_143045205.1	RloB domain-containing protein	-
DPR03_RS15715	3641..4930	-	1290	WP_071321328.1	ATP-binding protein	-
DPR03_RS15720	5158..5487	-	330	WP_071321327.1	hypothetical protein	-
DPR03_RS15725	5714..7063	-	1350	WP_071321326.1	MobA/MobL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..29258	29258

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12255.10 Da
• Isoelectric Point: 7.9835

>T107844 WP_145758468.1 NZ_CP030757:c2809-2489 [Acinetobacter schindleri]
MLFIETSIFTKQIKELLSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSMKDNLTDKETSILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T107844 NZ_CP030757:c2809-2489 [Acinetobacter schindleri]
ATGTTATTCATTGAAACCAGTATTTTTACCAAGCAAATCAAAGAGCTTTTGAGTGATGAAGAGTATCGTCAGCTTCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGCGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGTAAAAGTGGCGGTATCCGTGTGATCTATTACTGGGTCACAGAAGATGATCAGATATTTTTCCTGGTGGCTTAT
CCAAAGTCTATGAAAGATAATCTGACAGACAAAGAGACCTCTATTTTGCGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10126.59 Da
• Isoelectric Point: 7.2045

>AT107844 WP_004896911.1 NZ_CP030757:c2496-2224 [Acinetobacter schindleri]
MDNNLFDDLVASIKEAGAIKRNEMKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Nucleotide

• Length: 273 bp

>AT107844 NZ_CP030757:c2496-2224 [Acinetobacter schindleri]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAACGCAATGAAATGAAAGCAAG
CCGGGTAACTGAGCTTGAATTGCCGGATATTAAGGAAGTACGTGAGAAGACAGGCTTAACCCAAGCTGAATTTGCTGCAC
GTTTGCATATCAGTGCCAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACGCTAATT
CGTATTCTGGATGCCCATCCAACTCTGATTTAA