Detailed information of TA system TA107843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 14522..15107
• Replicon: plasmid unnamed2
• Accession: NZ_CP030756
• Organism: Acinetobacter schindleri strain H3

Toxin (Protein)

• Gene name: higB
• Uniprot ID: D4XK07
• Locus tag: DPR03_RS15595
• Protein ID: WP_004641922.1
• Coordinates: 14522..14842 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DPR03_RS15600
• Protein ID: WP_004641921.1
• Coordinates: 14835..15107 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPR03_RS15550	9624..9845	-	222	WP_004641946.1	hypothetical protein	-
DPR03_RS15555	9947..11383	-	1437	WP_004641944.1	MobA/MobL family protein	-
DPR03_RS15560	11593..11859	+	267	WP_143045203.1	mobilization protein	-
DPR03_RS15565	11874..12182	+	309	WP_081409073.1	hypothetical protein	-
DPR03_RS15575	12776..12964	+	189	WP_004641934.1	YqaE/Pmp3 family membrane protein	-
DPR03_RS15580	13586..13801	+	216	WP_004641928.1	cold-shock protein	-
DPR03_RS15585	13913..14140	+	228	WP_004641927.1	hypothetical protein	-
DPR03_RS15590	14210..14407	+	198	WP_004641925.1	hypothetical protein	-
DPR03_RS15595	14522..14842	+	321	WP_004641922.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DPR03_RS15600	14835..15107	+	273	WP_004641921.1	helix-turn-helix domain-containing protein	Antitoxin
DPR03_RS15605	15724..15921	+	198	WP_004282105.1	hypothetical protein	-
DPR03_RS15610	15988..17865	-	1878	WP_048882685.1	potassium transporter Kup	-
DPR03_RS15615	18238..18849	+	612	WP_004641910.1	recombinase family protein	-
DPR03_RS15625	19549..19977	+	429	WP_004282100.1	organic hydroperoxide resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..25870	25870

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12279.10 Da
• Isoelectric Point: 7.9849

>T107843 WP_004641922.1 NZ_CP030756:14522-14842 [Acinetobacter schindleri]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNRGKSSGIRVIYYWVIEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T107843 NZ_CP030756:14522-14842 [Acinetobacter schindleri]
ATGCTATTCATTGAAACCAGTATTTTTACCAAGCAAATCAAAGAGCTTGTAAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTGCAGCCTGATAAAGGTGACTTAATCAAGAATGGCGGTGGCATTCGTAAAGTACGCTGTGCTCAAGGTA
ATAGAGGAAAAAGTAGCGGTATCCGTGTGATCTACTATTGGGTCATAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATCCTGCGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10108.56 Da
• Isoelectric Point: 7.2045

>AT107843 WP_004641921.1 NZ_CP030756:14835-15107 [Acinetobacter schindleri]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Nucleotide

• Length: 273 bp

>AT107843 NZ_CP030756:14835-15107 [Acinetobacter schindleri]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATTAAAGAAGCTGGTGCCATCAAACGTAATGAGATAAAGGCTAG
TCGAGTCACAGAGCTTGAATTGCCAGATATTAAAGAAGTACGTGAGAAAACTGGATTAACGCAAGCAGAGTTTGCTGCAC
GTTTGCATATTAGCGCGAGAACGCTACAGAACTGGGAACAAGGCCGACGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGCATTCTGGATGCCCATCCAACTTTGATCTAA

Structures

Toxin

• AlphaFold DB: A0A1J4NBH7