Detailed information of TA system TA107833

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1473250..1473773
• Replicon: chromosome
• Accession: NZ_CP030715
• Organism: Staphylococcus pseudintermedius strain VB88

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DNH96_RS07120
• Protein ID: WP_096533652.1
• Coordinates: 1473250..1473516 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A3D8YKM0
• Locus tag: DNH96_RS07125
• Protein ID: WP_014612814.1
• Coordinates: 1473516..1473773 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DNH96_RS07100	1468502..1468648	-	147	WP_172426193.1	hypothetical protein	-
DNH96_RS07110 (DNH96_07080)	1471281..1472774	+	1494	WP_014612817.1	L-lactate dehydrogenase (quinone)	-
DNH96_RS07115 (DNH96_07085)	1472788..1472889	+	102	WP_019169745.1	SE2200 family small protein	-
DNH96_RS07120 (DNH96_07090)	1473250..1473516	-	267	WP_096533652.1	Txe/YoeB family addiction module toxin	Toxin
DNH96_RS07125 (DNH96_07095)	1473516..1473773	-	258	WP_014612814.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DNH96_RS07130 (DNH96_07100)	1473966..1475870	-	1905	WP_096533653.1	triacylglycerol lipase	-
DNH96_RS07135 (DNH96_07105)	1476130..1476624	+	495	WP_015729749.1	isoprenylcysteine carboxylmethyltransferase family protein	-
DNH96_RS07140 (DNH96_07110)	1476936..1477724	-	789	WP_063284837.1	arylamine N-acetyltransferase	-
DNH96_RS07145 (DNH96_07115)	1478254..1478436	+	183	WP_063278657.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10565.19 Da
• Isoelectric Point: 10.2281

>T107833 WP_096533652.1 NZ_CP030715:c1473516-1473250 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKPLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYLRRLNHQHRVVYTVDDEKREVYI
FSAWSHYE

Nucleotide

• Length: 267 bp

>T107833 NZ_CP030715:c1473516-1473250 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTTTTAATTAAGAATTCAGCCAAAAATGACTTAAAAAAAATTAAAAAGCCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTTAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCACATTATGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.87 Da
• Isoelectric Point: 4.1100

>AT107833 WP_014612814.1 NZ_CP030715:c1473773-1473516 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT107833 NZ_CP030715:c1473773-1473516 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3D8YKM0