Detailed information of TA system TA107828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 443793..444316
• Replicon: chromosome
• Accession: NZ_CP030374
• Organism: Staphylococcus pseudintermedius strain AH18

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DNH82_RS01885
• Protein ID: WP_096533652.1
• Coordinates: 443793..444059 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A3D8YKM0
• Locus tag: DNH82_RS01890
• Protein ID: WP_014612814.1
• Coordinates: 444059..444316 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DNH82_RS01875 (DNH82_01905)	441824..443317	+	1494	WP_014612817.1	L-lactate dehydrogenase (quinone)	-
DNH82_RS01880 (DNH82_01910)	443331..443432	+	102	WP_019169745.1	SE2200 family small protein	-
DNH82_RS01885 (DNH82_01915)	443793..444059	-	267	WP_096533652.1	Txe/YoeB family addiction module toxin	Toxin
DNH82_RS01890 (DNH82_01920)	444059..444316	-	258	WP_014612814.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DNH82_RS01895 (DNH82_01925)	444509..446413	-	1905	WP_096533653.1	triacylglycerol lipase	-
DNH82_RS01900 (DNH82_01930)	446673..447167	+	495	WP_015729749.1	isoprenylcysteine carboxylmethyltransferase family protein	-
DNH82_RS01905 (DNH82_01935)	447479..448267	-	789	WP_063284837.1	arylamine N-acetyltransferase	-
DNH82_RS01910 (DNH82_01940)	448797..448979	+	183	WP_063278657.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10565.19 Da
• Isoelectric Point: 10.2281

>T107828 WP_096533652.1 NZ_CP030374:c444059-443793 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKPLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYLRRLNHQHRVVYTVDDEKREVYI
FSAWSHYE

Nucleotide

• Length: 267 bp

>T107828 NZ_CP030374:c444059-443793 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTTTTAATTAAGAATTCAGCCAAAAATGACTTAAAAAAAATTAAAAAGCCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTTAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCACATTATGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.87 Da
• Isoelectric Point: 4.1100

>AT107828 WP_014612814.1 NZ_CP030374:c444316-444059 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT107828 NZ_CP030374:c444316-444059 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3D8YKM0