Detailed information of TA system TA107805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 912540..913270
• Replicon: chromosome
• Accession: NZ_CP030347
• Organism: Enterobacter hormaechei strain AR_038

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A837FIL2
• Locus tag: CSB67_RS05730
• Protein ID: WP_023302825.1
• Coordinates: 912956..913270 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CSB67_RS05725
• Protein ID: WP_023302826.1
• Coordinates: 912540..912959 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB67_RS05700	907988..909493	-	1506	WP_032634219.1	signal transduction histidine-protein kinase/phosphatase UhpB	-
CSB67_RS05705	909490..910083	-	594	WP_003861054.1	transcriptional regulator UhpA	-
CSB67_RS05710	910209..910496	-	288	WP_015570113.1	acetolactate synthase small subunit	-
CSB67_RS05715	910500..912188	-	1689	WP_023302827.1	acetolactate synthase large subunit	-
CSB67_RS05720	912295..912393	-	99	WP_057979964.1	ilvB operon leader peptide IvbL	-
CSB67_RS05725	912540..912959	-	420	WP_023302826.1	helix-turn-helix domain-containing protein	Antitoxin
CSB67_RS05730	912956..913270	-	315	WP_023302825.1	type II toxin-antitoxin system HigB family toxin	Toxin
CSB67_RS05735	913757..913846	+	90	WP_017383683.1	type I toxin-antitoxin system toxin TisB	-
CSB67_RS05740	913911..914357	+	447	WP_003861064.1	GNAT family N-acetyltransferase	-
CSB67_RS05745	914420..915253	+	834	WP_032620535.1	DMT family transporter	-
CSB67_RS05750	915429..916613	+	1185	WP_015570118.1	multidrug efflux MFS transporter EmrD	-
CSB67_RS05755	916519..917604	-	1086	Protein_889	cellulase family glycosylhydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (84-136)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12415.51 Da
• Isoelectric Point: 10.2825

>T107805 WP_023302825.1 NZ_CP030347:c913270-912956 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Nucleotide

• Length: 315 bp

>T107805 NZ_CP030347:c913270-912956 [Enterobacter hormaechei]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15380.96 Da
• Isoelectric Point: 5.2068

>AT107805 WP_023302826.1 NZ_CP030347:c912959-912540 [Enterobacter hormaechei]
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANGPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Nucleotide

• Length: 420 bp

>AT107805 NZ_CP030347:c912959-912540 [Enterobacter hormaechei]
ATGATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGA
GAAAGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGTCCTTTGCTGGATATTGTGT
GCGCCAGAATTAGCCATTACGAAGCTAATGGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGA
ATTGCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGAT
GGTTTCACGGGTTCTGAATGGTCAGAGACAGCTTACCCTGAACCATATTAAAAAGCTGGCGGCCAGATTTGGGGTATCAC
CTGCGTTATTTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A837FIL2